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http://dx.doi.org/10.1111/dom.16546 | DOI Listing |
BMJ Case Rep
September 2025
Ophthalmology, Federal University of Parana, Curitiba, Brazil
Neuroretinitis (NR) is characterised by optic disc oedema associated with macular exudates in a star-shaped pattern. Several aetiologies of NR have been described, with cat-scratch disease being the most common. However, despite thorough investigations, one-quarter of cases are classified as idiopathic neuroretinitis (INR), in which visual prognosis is generally good.
View Article and Find Full Text PDFObjectives: To investigate whether quantitative retinal markers, derived from multimodal retinal imaging, are associated with increased risk of mortality among individuals with proliferative diabetic retinopathy (PDR), the most severe form of diabetic retinopathy.
Design: Longitudinal retrospective cohort analysis.
Setting: This study was nested within the AlzEye cohort, which links longitudinal multimodal retinal imaging data routinely collected from a large tertiary ophthalmic institution in London, UK, with nationally held hospital admissions data across England.
Cell Signal
September 2025
Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No. 81 Meishan Road, Hefei 230032, Anhui, China; Engin
Leber's hereditary optic neuropathy (LHON), a mitochondrial disorder marked by central vision loss, exhibits incomplete penetrance and male predominance. Since there are no adequate models for understanding the rapid vision loss associated with LHON, we generated induced pluripotent stem cells (iPSCs) from LHON patients carrying the pathogenic m.3635G > A mutation and differentiated them into retinal pigment epithelium (RPE) cells.
View Article and Find Full Text PDFExp Eye Res
September 2025
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Hongkou District, Shanghai, 200080, China. Electronic address:
Purpose: A disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) has been found to increase and to be associated with diabetic retinopathy (DR). The study aimed to identify the role of ADAMTS13 in the pathogenesis of angiogenesis in DR.
Methods: ADAMTS13 expression was evaluated in human retinal microvascular endothelial cells (HRMVECs), vitreous sample from patients with proliferative DR and diabetic mice model using western blot, real time-quantitative PCR, immunofluorescence and ELISA.
Exp Eye Res
September 2025
School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, 266071, China; Department of Ophthalmology, Qingdao Eighth People's Hospital, Qingdao, Shandong Province, 266121, China; Institute of Stem Cell Regeneration Medicine, School of Basic Medicine, Qingdao University, Qingdao, Shan
Mitochondria play a crucial role in energy production and are intimately associated with ocular function. Mitochondrial dysfunction can trigger oxidative stress and inflammation, adversely affecting key ocular structures such as the lacrimal gland, lens, retina, and trabecular meshwork. This dysfunction may compromise the barrier properties of the trabecular meshwork, impeding aqueous humour outflow, elevating intraocular pressure, and resulting in optic nerve damage and primary open-angle glaucoma.
View Article and Find Full Text PDF