Resonant recognition model-guided biophysical insights into POMC, leptin, adiponectin, BDNF, insulin, irisin, GDF-15 interactions & executing PBMT targeting leptin/BDNF circuit to attenuate obesity.

Obesity poses a major health concern. Synthetic compounds offer potential but come with adverse effects. Earlier Photo-Bio-Modulation (PBM) research was hindered by unclear parameter selection, notably in wavelength choice. The Resonant Recognition Model (RRM) proposes targeting specific protein-receptor pairs to activate anti-obesity mechanisms. The experiment aims to generate precise wavelengths using the RRM, simulated in MATLAB 2022b. It combines LED and LASER technologies targeting desired proteins through specific anatomical areas. An obese mouse model was induced via Monosodium L-glutamate (MSG) injections followed by a high-fat diet (HFD) with varied dietary conditions. Wavelengths for POMC, BDNF, Adiponectin, Insulin, Irisin, GDF-15, and Leptin were measured, where Leptin and BDNF pathways were validated experimentally using LED arrays (650-750 nm, 1.12mW and 500-535 nm, 1.12mW) and a laser (532 nm, < 500mW) over 10 days, with continuous monitoring of body weight and food intake. Treatment groups showed significant improvements in lipid profile, liver enzymes, inflammatory markers, and heightened SOD activity. This claimed anti-obesity potential and reversed leptin resistance through the restored leptin and BDNF-leptin circuit activity. The study's success in mitigating obesity within 10 days, sans apparent side effects, sets a precedent for disease and protein-specific wavelength selection. Clinical trial number Not applicable.