Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Phenylketonuria (PKU) is a rare disease. Children who are diagnosed with PKU often encounter psycho-behavioral difficulties, which can significantly impact quality of life and social integration. The aim of this study was to evaluate the prevalence of psycho-behavioral difficulties and explore potential factors associated with their occurrence in PKU children aged 6-18 years.
Methods: From May 2022 to May 2024, 100 children with PKU were recruited using a questionnaire-based survey. Data were analyzed using the STATA (version 18.0) and R programming language (version 4.3.3).
Results: 25% of children aged 6-18 years with PKU exhibited psycho-behavioral problems. Significant factors associated with psycho-behavioral problems in study children included body mass index (multi-adjusted odds ratio, 95% confidence interval, P: 1.135, 1.010-1.276, 0.033), age (3.169, 1.024-9.804, 0.045), pregnancy order (0.143, 0.033-0.607, 0.008), delivery order (0.041, 0.004-0.373, 0.005), mode of disease diagnosis (5.730, 1.935-16.963, 0.002), and dietary therapy pressure (3.321, 1.083-10.181, 0.036). Based on these significant factors, a nomogram model was constructed with descent prediction capability and accuracy.
Conclusions: We identified six factors closely associated with psycho-behavioral problems in PKU children, offering insights into risk profiles underlying these problems and guiding the formulation of effective prevention strategies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153110 | PMC |
| http://dx.doi.org/10.1186/s13023-025-03824-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Therapeutic outcomes of GnRHa and rhGH in idiopathic central precocious puberty: a focus on psychological and behavioral improvements.
BMC Pediatr
August 2025
Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, 350005, Fujian Province, China.
Objective: The psychological issues associated with idiopathic central precocious puberty (ICPP) in girls remain a contentious topic, particularly regarding the necessity and effectiveness of psychological interventions and pharmacological treatments such as gonadotropin-releasing hormone analog (GnRHa) or GnRHa combined with recombinant human growth hormone (rhGH).
Methods: This study aimed to assess the psychological profiles of 95 ICPP girls and their parents, comparing them with 70 healthy controls, and to investigate the potential therapeutic effects of pharmacological interventions. For parents, psychological evaluations were conducted using the Child Behavior Checklist, State Anxiety Inventory, and Positive and Negative Affect Schedule.
Factors associated with psycho-behavioral problems among 100 children with phenylketonuria aged 6-18 years.
Orphanet J Rare Dis
June 2025
Center for Evidence-Based Medicine, Capital Institute of Pediatrics and Capital Center for Children's Health, Capital Medical University, Beijing, China.
Background: Phenylketonuria (PKU) is a rare disease. Children who are diagnosed with PKU often encounter psycho-behavioral difficulties, which can significantly impact quality of life and social integration. The aim of this study was to evaluate the prevalence of psycho-behavioral difficulties and explore potential factors associated with their occurrence in PKU children aged 6-18 years.
View Article and Find Full Text PDFSexual Victimization and Psychological and Behavioral Outcomes Among Children and Adolescents in South Korea.
Psychiatry Investig
May 2025
Department of Social Welfare, Sungkyunkwan University, Seoul, Republic of Korea.
Objective: By focusing on a person-centered approach using latent class analyses (LCA), this study examined the patterns of sexual victimization among children and adolescents in South Korea and compared the psycho-behavioral outcomes of these classes.
Methods: Participants were 546 females aged 6-17, including 117 sexual victimization survivors and 429 non-victims in South Korea. LCA, an analysis of covariance, and Bonferroni post-hoc tests were conducted.
A scoping review of literature: What has been studied about mental health problems among individuals with ankylosing spondylitis?
Arch Psychiatr Nurs
April 2025
School of Nursing, The Hong Kong Polytechnic University, Hong Kong. Electronic address:
Background: Research on mental health problems in individuals with ankylosing spondylitis (AS) has rapidly expanded since 2013. However, the evidence in this field can appear fragmented due to the limited number of existing reviews that synthesize research findings.
Aim: To map the evidence regarding the prevalence, correlated factors, and interventions for mental health problems in the AS population.
Modifiable Factors Underlying Caregivers' Psychological Support Needs in Pediatric Disability: Through the Lens of Psycho-Behavioral and Social-Environmental Interactions.
Healthcare (Basel)
March 2025
School of Public Health, Fudan University, Shanghai 200032, China.
: Childhood disability is a major stressor for caregivers. There are many problems and challenges in relation to satisfying the psychological support needs of caregivers. This study aims to explore the modifiable psycho-behavioral and social-environmental factors of psychological support needs and need satisfaction, their interaction effects, and their configuration paths.
View Article and Find Full Text PDF