Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
ObjectiveTo examine the effects of chronic alcohol consumption on brain functional connectivity using resting-state functional magnetic resonance imaging and degree centrality analysis.MethodsThis was a cross-sectional study, with participants including 23 light-to-moderate drinkers, 25 heavy drinkers, and 29 healthy controls aged 40-60 years. Degree centrality analysis was used to compare brain function differences among groups, and the relationships between degree centrality values, cognitive scores, and drinking behaviors were explored.ResultsHeavy drinkers showed significantly reduced degree centrality values in the left inferior temporal gyrus compared with healthy controls as well as in the left inferior temporal gyrus and left middle occipital gyrus compared with light-to-moderate drinkers. Degree centrality values in the left inferior temporal gyrus and left middle occipital gyrus were negatively correlated with drinking frequency and Michigan Alcoholism Screening Test scores but were positively correlated with cognitive scores.ConclusionsHeavy drinking significantly disrupts brain functional networks. These findings suggest a potential link between cognitive function and drinking behavior, which may inform future research on early interventions aimed at protecting brain function in chronic alcohol users.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152390 | PMC |
| http://dx.doi.org/10.1177/03000605251345891 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Association between the rs6656401 Locus of the CR1 Gene and Structural Alterations of Brain Effects in Han Chinese Patients with Alzheimer's Disease.
Curr Alzheimer Res
September 2025
Department of Neurology, the Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.
Introduction: The complement receptor 1 (CR1) gene is identified as the one closely associated with Alzheimer's disease (AD). However, there has been no exploration of the imaging alterations associated with the CR1 gene in AD patients of the Han population. The purpose of this study is to investigate the association between the rs6656401 mutation and neuroimaging variations in Han AD patients.
View Article and Find Full Text PDFBrain functional alterations in type 2 diabetes with obstructive sleep apnea patients: A multicenter resting-state fMRI study.
Sleep Med
August 2025
Department of Radiology Imaging Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, PR China. Electronic address:
Objective: This multicenter study aimed to investigate resting-state brain functional alterations in patients with type 2 diabetes mellitus (T2DM) comorbid with obstructive sleep apnea (OSA), and to elucidate the underlying neural mechanisms.
Methods: A total of 139 participants were enrolled from two centers, including 48 healthy controls (HCs), 46 T2DM patients, and 45 T2DM with OSA patients. Resting-state functional magnetic resonance imaging (rs-fMRI) was used to assess brain function using degree centrality (DC), amplitude of low-frequency fluctuation (ALFF), and seed-based functional connectivity (FC).
Network spatial patterns and determinants of China's hometown chambers of commerce.
PLoS One
September 2025
Institute of Western China Economic Research, Southwestern University of Finance and Economics, Chengdu, Sichuan, China.
Based on the establishment data of provincial-provincial, city-city, provincial-city, city-provincial Hometown Chambers of Commerce (HCCs) in China by the end of 2022, this paper combines social network analysis and exponential random graph model to explore network spatial patterns and determinants of China's HCCs. Findings indicate that: 1) Point degree centrality in eastern China is high, but spatial patterns vary across network types: provincial-provincial and provincial-city types exhibit a "rhombus-net" pattern, the city-city type follows a "small-ring-line" structure, and the city-provincial type forms a "large-ring-net" type. Guangdong, Fujian, Zhejiang, Jiangxi, and Shandong constitute core areas of China's HCC network, and provincial-provincial and city-city types mainly flow within the core area and from core to periphery, while provincial-city and city-provincial types flow mutually between core and periphery areas.
View Article and Find Full Text PDFThe ceRNA Regulatory Network in Vitiligo: Evidence from Bioinformatics Analysis.
Clin Cosmet Investig Dermatol
August 2025
Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, People's Republic of China.
Background: Vitiligo is an acquired depigmentary disorder caused by the loss of functional melanocytes. Increasing evidence suggests that competing endogenous RNA (ceRNA) interactions participate in this process, yet their global architecture in vitiligo remains unclear.
Objective: To delineate a long non-coding RNA (lncRNA)-microRNA (miRNA)-mRNA ceRNA network associated with vitiligo and to identify blood-borne RNA markers with diagnostic potential.
Altered voxel-wise degree centrality of brain networks in patients with chronic rhinosinusitis: a resting-state functional magnetic resonance imaging study.
Quant Imaging Med Surg
September 2025
Department of Ophthalmology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disorder of the paranasal sinus and nasal cavity. Previous studies have demonstrated that patients with CRS have an increased risk of emotional and cognitive disorders. Although neuroimaging studies have identified brain alterations in CRS, the specific etiology of these neurological changes remains unclear.
View Article and Find Full Text PDF