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Article Abstract
The asymmetric cycloaddition reaction of -quinone monoimides is a significant research focus for constructing benzofused heterocycles. However, due to steric effects, achieving efficient cycloaddition at highly sterically hindered site is challenging but practically valuable. Herein, we develop an asymmetric [3 + 2] cycloaddition reaction of -quinone monoimides with 1-vinylnaphthalen-2-ols and 3-vinylindoles via steric hindrance-overcoming strategy. Binaphthalene-based chiral phosphoric acid catalyzes the asymmetric cycloaddition reaction to synthesize highly functionalized 2,3-dihydrobenzofurans in generally good yields with good to excellent stereoselectivities.
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| http://dx.doi.org/10.1021/acs.joc.5c00764 | DOI Listing |
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