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Residues of pharmaceuticals and personal care products (PPCPs) in drinking water pose significant public health risks. To assess these residues in water, this study developed a solid-phase extraction combined with ultra-performance liquid chromatography-tandem mass spectrometry method (SPE-UPLC-MS/MS) for the simultaneous quantitative determination of 98 PPCP residues in drinking water. By optimizing the pretreatment method and analysis conditions, the method exhibits excellent linearity, with all PPCPs showing correlation coefficients () greater than 0.99 within the concentration range of 0-100 μg L. Recovery rates ranged from 60.7% to 119.0%, and the relative standard deviations (RSDs) were below 20%. The limits of detection (LODs) were between 0.034 and 4.001 ng L. Residues such as amisulpride and 1,7-dimethylxanthine were detected in water samples. This method is simple, sensitive, and suitable for high-throughput detection of trace PPCPs in drinking water, providing reliable technical support for water quality monitoring.
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http://dx.doi.org/10.1039/d5ay00307e | DOI Listing |
Int J Surg
September 2025
Department of Data Science, City University of Hong Kong, Hong Kong, SAR, China.
Background: Water hardness, which refers to the level of dissolved calcium and magnesium salts, is of significant public health concern due to its potential impact on health. The association between water hardness and digestive diseases remains underexplored, with limited evidence from small-scale clinical studies. Given the rising prevalence of digestive disorders worldwide, large-scale cohort studies are needed to address this gap in the literature.
View Article and Find Full Text PDFJ Oral Pathol Med
September 2025
Department of Oral and Maxillofacial Pathology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Background: Oral squamous cell carcinoma (OSCC) is one of the most frequent head and neck cancers. The 4-nitroquinoline 1-oxide (4NQO) mouse model of oral carcinogenesis is a well-established model to investigate the mechanism behind OSCC development, including epigenetic alterations. Studies have shown that histone acetylation is a key regulator of gene expression and may play a role in such a tumor.
View Article and Find Full Text PDFVet World
July 2025
Department of Animal Science, Faculty of Agriculture, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Background And Aim: Antibiotic resistance has spurred interest in alternative feed additives for poultry. Wood vinegar (WV), a by-product of plant pyrolysis, contains bioactive compounds with antioxidant and antimicrobial properties. This study aimed to evaluate the effects of WV supplementation through drinking water on the cecal microbial population, volatile fatty acid (VFA) concentrations, antioxidant enzyme activity, and apparent ileal nutrient digestibility in broiler chickens.
View Article and Find Full Text PDFAlcohol Clin Exp Res (Hoboken)
September 2025
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
Background: Alcohol use disorder (AUD) is a pervasive problem in society afflicting millions of people worldwide. One reason for the prevalence of AUD is that heavy alcohol drinking can produce alcohol dependence. In addition, alcohol dependence dysregulates the body's stress systems to increase alcohol drinking.
View Article and Find Full Text PDFJ Mol Neurosci
September 2025
Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
The ketogenic diet (KD), a high-fat, low-carbohydrate regimen, has been shown to exert neuroprotective effects in various neurological models. This study explored how KD-alone or combined with antibiotic-induced gut microbiota depletion-affects cognition and neuroinflammation in aging. Thirty-two male rats (22 months old) were assigned to four groups (n = 8): control diet (CD), ketogenic diet (KD), antibiotics with control diet (AB), and antibiotics with KD (KDAB).
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