Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Intensive care units (ICUs) are critical environments for the emergence of antibiotic-resistant bacteria, with numerous studies focusing on resistant pathogens in these settings. However, transferable antibiotic resistance plasmids (TARPs)-regardless of their origin from pathogenic or non-pathogenic bacteria-are key drivers of resistance gene dissemination and the emergence of resistant strains. This study investigated TARPs in ICU air. Air samples were directly used to isolate resistant plasmids using CV601 as the recipient. Plasmid types, antibiotic resistance genes (ARGs), and virulence factors were identified through sequencing, and resistance phenotypes were validated. A total of 30 distinct plasmid types were detected, with IncX3 being the most prevalent. Among 245 ARGs identified, , , and were dominant. Phylogenetic analysis indicated that these TARPs originated from bacteria commonly colonizing human mucosa. ICU airborne TARPs may significantly contribute to the spread of ARGs and antibiotic resistance transmission.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052693 | PMC |
| http://dx.doi.org/10.1016/j.isci.2025.112254 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synergistic antimicrobial and antibiofilm effects of plant-active ingredients and antibiotics on multidrug-resistant Acinetobacter baumannii.
J Appl Microbiol
September 2025
Sivas Cumhuriyet University, Faculty of Medicine, Department of Medical Microbiology, 58140 Sivas, Türkiye.
Aims: The increasing antimicrobial resistance, particularly in Acinetobacter baumannii, complicates the treatment of infections, leading to higher morbidity, mortality, and economic costs. Herein, we aimed to determine the in vitro antimicrobial, synergistic, and antibiofilm activities of colistin (COL), meropenem, and ciprofloxacin antibiotics, and curcumin, punicalagin, geraniol (GER), and linalool (LIN) plant-active ingredients alone and in combination against 31 multidrug-resistant (MDR) A. baumannii clinical isolates.
View Article and Find Full Text PDFAnti-plasmid defense in hypervirulent involves Type I-like and Type IV restriction modification systems.
Emerg Microbes Infect
September 2025
Infectious Diseases Translational Research Programme, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Hypervirulent (hvKp) and classical multidrug-resistant (MDR) strains belong to distinct lineages and hvKp are typically characterized by hypermucoid capsules that have been shown to limit horizontal gene transfer (HGT), including plasmid acquisition. However, the convergence of hypervirulence and MDR is increasingly common worldwide. When we profiled 127 antibiotic-susceptible hvKp strains, we found that most (86%) are highly permissive to plasmid transfer despite their capsules.
View Article and Find Full Text PDFEffects of metformin on gut microbiota and short/mediumchain fatty acids in highfat diet rats.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Laboratory Animal Science, Xiangya School of Medicine, Central South University, Changsha 410013, China.
Objectives: Recent evidence suggests that the gut may be a primary site of metformin action. However, studies on the effects of metformin on gut microbiota remain limited, and its impact on gut microbial metabolites such as short-/medium-chain fatty acids is unclear. This study aims to investigate the effects of metformin on gut microbiota, short-/medium-chain fatty acids, and associated metabolic benefits in high-fat diet rats.
View Article and Find Full Text PDFOvercoming Multi-Drug-Resistant Infections.
Microb Drug Resist
September 2025
Students Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Antimicrobial resistance (AMR) is one of the most important concerns in the world, occurring for both Gram-positive and Gram-negative bacteria. () is a Gram-negative bacterium belonging to the family of Enterobacteriaceae and also plays an important role in development of nosocomial infections. Three forms have emerged as a result of AMR including multi-drug resistant (MDR), extensively drug-resistant, and pan-drug-resistant.
View Article and Find Full Text PDFClinical Implications and Patient Outcomes Associated with otic Resistance in Saudi Arabian Intensive Care Unit Facilities: A Perspective.
Curr Rev Clin Exp Pharmacol
September 2025
Department of Clinical Practice, College of Pharmacy, Jazan University, Saudi Arabia.
Introduction: Antimicrobial Resistance (AMR) poses a significant global health threat, leading to increased morbidity, mortality, and healthcare costs. Intensive Care Units (ICUs) are particularly susceptible to AMR due to frequent invasive procedures, extended hospital stays, and the selective pressure exerted by broad-spectrum antibiotics. This review aims to shed light on the current landscape of antibiotic resistance within ICUs of Saudi hospitals.
View Article and Find Full Text PDF