Clinical Implications and Patient Outcomes Associated with otic Resistance in Saudi Arabian Intensive Care Unit Facilities: A Perspective.

Introduction: Antimicrobial Resistance (AMR) poses a significant global health threat, leading to increased morbidity, mortality, and healthcare costs. Intensive Care Units (ICUs) are particularly susceptible to AMR due to frequent invasive procedures, extended hospital stays, and the selective pressure exerted by broad-spectrum antibiotics. This review aims to shed light on the current landscape of antibiotic resistance within ICUs of Saudi hospitals. It also explores molecular patterns of bacterial resistance and identifies potential strategies to address this issue. Additionally, it discusses the challenges in implementing these strategies within the Saudi healthcare system.

Methods: We conducted a literature search across electronic databases, including Web of Science, PubMed, EMBASE, Scopus, and Google Scholar, until September 30th, 2024, to identify relevant studies. Selected studies were analyzed to extract insights into prevailing bacterial resistance trends in Saudi ICUs and the molecular mechanisms responsible.

Results: Our findings provide an overview of the current state of AMR in Saudi ICUs, including the emergence and prevalence of specific molecular patterns of bacterial resistance. Moreover, it presents potential strategies to combat antibiotic resistance, including antimicrobial stewardship programs, infection control measures, and the development of new antibiotics. It also highlights the inherent challenges in implementing these strategies within the unique healthcare landscape of Saudi Arabia.

Discussion: The increasing emergence and spread of MDR bacteria in Saudi Arabia are attributed to the unoptimized antibiotic use, over-the-counter antibiotics without prescription, a high volume of international travellers, and challenges in adherence to infection control practices. Addressing the challenges and implementing effective prevention strategies are critical to maintaining antibiotic efficacy and combating AMR. Several strategies have been employed by the National AMR Committee, in partnership with WHO, to address antibiotic resistance in intensive care units.

Conclusion: AMR in Saudi ICUs is a pressing concern requiring immediate attention. A multifaceted approach combining surveillance, education, and policy interventions is essential to overcome this issue. Addressing AMR is crucial for global efforts to preserve the efficacy of antibiotics and maintain the effectiveness of critical healthcare interventions.