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As we humans continue our detrimental activities on the planet, the biodiversity loss is now seen as a big threat to entire ecosystem in which we all live. This issue becomes even more critical as we see a rapid increase in the number of animal species being listed as endangered, and a far greater rate of species extinction. We all know that felines play a crucial part in our ecosystems, it is therefore safe to argue that their conservation could play an important role in minimizing the biodiversity loss. Advanced reproductive biotechnologies including testicular tissue cryopreservation and transplantation are considered as effective tools for the conservation of animal species. As we have seen with the Giant Panda, these biotechnologies could offer new possibilities for the conservation of other endangered species including felines. Although previously a few wild feline spp. were conserved by this method, little is known about the factors influencing the efficiency of these methods. Therefore, if we are to maximize the conservation efforts, further optimization of these biotechnologies is required to achieve better conservation results. In this article, we present an overview of testicular tissue of felines and the factors influencing testicular tissue cryopreservation and testicular graft recovery in felines.
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http://dx.doi.org/10.3389/fvets.2025.1572150 | DOI Listing |
Front Cell Dev Biol
August 2025
Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, China.
Background: Methotrexate (MTX), a folate antagonist, is widely used in the treatment of tumors and autoimmune diseases such as rheumatoid arthritis (RA), due to its antiproliferative, antimetabolic, and potent anti-inflammatory properties. However, high-dose or long-term use of MTX can result in toxicity to the gastrointestinal, hemopoietic, and reproductive tissues. Yunpi Jiedu Tongluo Qushi Decoction (YJT), an effective Chinese herbal formula, is utilized in RA treatment to mitigate the toxic and side effect of MTX.
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August 2025
Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, China.
The gut microbiota, comprising trillions of bacteria, fungi, and viruses, exists in symbiosis with the host. As the largest microbial ecosystem in the human body. The gut microbiota not only shapes the homeostasis of the intestinal microenvironment through gut-derived metabolites but also exerts regulatory effects on the functions of diverse tissues and organs throughout the body via the intricate "gut-distal organ axis" mechanism.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Biomedical Science, Faculty of Medicine, Universitas Surabaya, Indonesia.
Introduction And Importance: One of the risk factors linked to mortality in Fournier Gangrene (FG) is the elderly. When this risk is present and diagnosed too late, patient care may become difficult. This case report discusses the treatment of an older patient with late-diagnosed Fournier's gangrene and its consequences in this background.
View Article and Find Full Text PDFCancer Med
September 2025
Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Background: Cisplatin is a commonly used chemotherapeutic across numerous cancer types that can cause neurotoxicities in patients, including peripheral sensory neuropathy, tinnitus, hearing loss, and vertigo.
Objective: We aimed to evaluate, for the first time, how genetic ancestry impacts cisplatin-induced neurotoxicities and if disparities are related to population differences in allele frequency.
Methods: In a cohort of cisplatin-treated testicular cancer survivors, relationships between genetic ancestry and neurotoxicities, medications, and lifestyle factors were assessed using logistic regression and Kruskal-Wallis tests and multiple pairwise comparisons using the Wilcoxon rank-sum test (Benjamini-Hochberg adjustment).
Reprod Biol
September 2025
Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran; Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; Preclinical Lab, Core Facility, Ker
Radiation and doxorubicin (Dox) exert destructive effects on testicular tissue. Resveratrol, a natural antioxidant, may protect the spermatogenic system against the toxic effects of these agents. This study evaluated the protective and antioxidant properties of resveratrol-loaded solid lipid nanoparticles (RES-SLNs) against Dox- and radiation-induced testicular injury in mice.
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