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The reproductive system is a vital component of the human body. In modern society, due to various socio-economic reasons, an increasing number of couples are choosing to postpone childbearing. Research into the impact of aging on the reproductive system is becoming increasingly important. As people age, there is a decline in the reproductive system across various levels, from the testes in males to spermatogonia cells, and from the ovaries in females to oocytes. The aging of the reproductive system not only affects the system itself but also has implications for other organs and systems in the body. Conversely, the aging of other organs and systems can also damage the reproductive system. This review organizes the changes that occur within the reproductive system as a result of aging and focuses on the interactions between the reproductive system and other systems. Additionally, this review summarizes current therapies aimed at delaying aging, which may provide insights for future interventions targeting the aging of the reproductive system and other systems.
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http://dx.doi.org/10.1096/fj.202403410R | DOI Listing |
J Eval Clin Pract
September 2025
Macquarie University Ethics and Agency Research Centre, Macquarie University, Sydney, New South Wales, Australia.
Rationale: Clinical innovation-where physicians develop and use novel interventions that differ significantly from standard practice and that have not been shown to be sufficiently safe or effective for regular use in healthcare systems-has the potential to transform patient care and drive medical advancement. However, it is not without risk. It is important, therefore, that policymakers and healthcare institutions develop strategies to encourage responsible clinical innovation.
View Article and Find Full Text PDFJ Cell Physiol
September 2025
Jiangxi Province Key Laboratory of Immunology and Inflammation, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Ovarian granulosa cells (GCs) are pivotal for follicular homeostasis, and their dysregulated apoptosis drives age-related ovarian aging. The Hippo signaling pathway, modulated by long noncoding RNAs (lncRNAs), is implicated in regulating GCs proliferation and ovarian aging. TEAD2 (Transcriptional Enhanced Associate Domain 2), a key downstream transcription factor of the Hippo signaling pathway, plays a critical role in regulating cell proliferation, apoptosis, and embryonic stem cell self-renewal.
View Article and Find Full Text PDFExp Ther Med
October 2025
Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Immune-related factors may serve an important role in the development of endometriosis, considering the occurrence of substantial abnormalities in the immune system of women with endometriosis, including reduced T-cell reactivity and natural killer cell cytotoxicity, as well as increased numbers and activation of peritoneal macrophages. Moreover, women suffering from endometriosis are at a higher risk for developing various autoimmune diseases as comorbidities of endometriosis. Recent epidemiological data demonstrate that patients with endometriosis have a significantly higher risk (2.
View Article and Find Full Text PDFFront Glob Womens Health
August 2025
Department of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.
Background: Vulvovaginal Candidiasis (VVC) is a condition commonly caused by . It is the second most common infection of the female genitalia affecting many women worldwide. Studies have identified unhealthy genital care practices to be associated with the infection among women including expectant mothers.
View Article and Find Full Text PDFFront Oncol
August 2025
Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Background: Low-grade endometrial stromal sarcoma (LG-ESS) is a rare malignant tumor of the female reproductive system with atypical clinical symptoms and slow progression.
Case: A 44-year-old female with a history of intermittent severe dysmenorrhea, previous laparoscopic myomectomy, and uterine artery embolization (UAE) presented with rapidly enlarging pelvic masses. Imaging revealed uterine masses suggestive of leiomyomas, although an adnexal origin could not be excluded.