98%
921
2 minutes
20
Objective: To clarify the feasibility and the anatomical characteristics related to round window exposure via the external auditory canal (EAC) without bony removal.
Methods: Surgical videos and radiological data from 50 adult patients who underwent endoscopic tympanoplasty type I were collected. According to surgical videos, round window niche (RWN) exposure was classified as "Certainly," "Possibly," and "None," and round window membrane (RWM) exposure was classified as "Clear visualization," "Incomplete visualization," "Just perceptible" and "Invisible." Basing on CT reconstruction, distances among RWM, RWN, tympanic annulus (TA), width, and orientation of scala tympani (ST) were measured under the Coordinate System of Cochlea, and anatomic features of EAC under the Coordinate System of EAC.
Results: 60% of RWNs were "Certainly," 24% "Possibly," and 16% "None" exposed. RWM exposure was 32% "Clear visualization," 22% "Incomplete visualization," 14% "Just perceptible," and 32% "Invisible." Longer distances between RWM and TA (RWM-TA), and the Width of ST in x and z sections were related to RWM exposure (RWM-TA: Spearman- = 0.663, , ST in x: Spearman- = -0.337, , z: Spearman- = -0.586, . RWM-TA longer than 7.06 mm indicated a possibility of RWM exposure (AUC = 0.784, Widths of ST in x and z sections shorter than 1.85 mm and 1.84 mm, respectively, indicated better RWM exposure (AUC = 0.887, ). The size of EAC in axial and coronal sections could significantly predict RWM exposure (axial: AUC = 0.726, , coronal: AUC = 0.798, ).
Conclusion: In adults, 54% of RWM could be partially visualized via EAC without bony removal. There are reliable pre-operative predictors for RWM exposure, which are helpful for future inner ear therapy.
Level Of Evidence: 3.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931666 | PMC |
http://dx.doi.org/10.1002/lio2.70127 | DOI Listing |
Lab Chip
May 2025
Department of Living Systems, Triton Systems, Inc., Chelmsford, MA, USA.
Most hearing loss often results from permanent damage to cochlear hair cells, and effective treatments remain limited. A reliable, scalable, and physiologically relevant ear model can accelerate the development of hearing-loss protection therapeutics for injury prevention and hearing restoration. The challenge remains on screening delivery systems for regenerative compounds, and no screening systems exist that capture the complexity of inner ear properties.
View Article and Find Full Text PDFLaryngoscope Investig Otolaryngol
April 2025
Department of Otolaryngology Head and Neck Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China.
Objective: To clarify the feasibility and the anatomical characteristics related to round window exposure via the external auditory canal (EAC) without bony removal.
Methods: Surgical videos and radiological data from 50 adult patients who underwent endoscopic tympanoplasty type I were collected. According to surgical videos, round window niche (RWN) exposure was classified as "Certainly," "Possibly," and "None," and round window membrane (RWM) exposure was classified as "Clear visualization," "Incomplete visualization," "Just perceptible" and "Invisible.
Neurotoxicol Teratol
May 2025
University of Cincinnati College of Medicine, Department of Pediatrics and Cincinnati Children's Hospital Medical Center, Division of Neurology, Cincinnati, OH 45229, USA. Electronic address:
The prevalence of attention deficit hyperactivity disorder (ADHD) is 9.8 % in U.S.
View Article and Find Full Text PDFAdv Healthc Mater
March 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, P. R. China.
Noise-induced hearing loss (NIHL) results from prolonged exposure to intense noise, causing damage to sensory outer hair cells (OHCs) and spiral ganglion neurons (SGNs). The blood labyrinth barrier (BLB) hinders systemic drug delivery to the inner ear. This study applied a retro-auricular round window membrane (RWM) method to bypass the BLB, enabling the transport of macromolecular proteins into the inner ear.
View Article and Find Full Text PDFBackground: To create and develop a delivery approach for clinical inner ear gene therapy, we conducted a study of trans-round window membrane (RWM) microinjection using a pipetting microneedle via transcanal endoscopic ear surgery (TEES).
Methods: The implementation of the trans-RWM microinjection surgery involved seven cadaveric specimens, and the surgical procedures and the pipetting microneedle were developed and optimized. The TEES procedures included tympanic cavity visualization, RWM exposure, stapes footplate perforation, and trans-RWM microinjection.