Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923326PMC
http://dx.doi.org/10.1007/s13139-024-00882-1DOI Listing

Publication Analysis

Top Keywords

ga-psma uptake
4
uptake subchondral
4
subchondral cyst
4
cyst false
4
false impression
4
impression disease
4
disease progression
4
progression lu-psma
4
lu-psma radioligand
4
radioligand therapy
4

Similar Publications

Purpose: Prostate-specific membrane antigen positron emission tomography (PSMA PET) is increasingly used to diagnose and stage prostate cancer. A PRIMARY score uses anatomical localization and uptake patterns to improve diagnostic accuracy. We evaluated the histopathology of patients with no uptake pattern (PRIMARY score 1) and the prevalence of intraductal carcinoma of the prostate (IDC-P) in this subset compared with those with an uptake pattern (PRIMARY score ≥ 2).

View Article and Find Full Text PDF

We designed and synthesized a novel type of PSMA radioligand incorporating (2, 3) β-branched aromatic α-amino acids within the linker segment of its structure. PET/CT imaging and biodistribution analysis revealed that β-branched aromatic α-amino acids modified PSMA radioligands could maintain or even improve tumor targeting while exhibiting a more rapid renal clearance rate than [Ga]Ga-. With average renal uptake of less than 10%ID/g, as opposed to 25%ID/g for [Ga]Ga-, this substantial decrease in renal accumulation translates to a significantly improved safety profile by minimizing nephrotoxic risks.

View Article and Find Full Text PDF

Purpose: While PSMA-targeted radioligand therapy (RLT) has shown remarkable efficacy for treating end-stage prostate cancer, the α-emitting RLT often results in severe salivary gland toxicity, limiting its use. Various strategies to mitigate this side effect have been attempted with limited success. Accordingly, this study introduced a new PSMA-targeting ligand with more favorable binding characteristics than the existing ligands.

View Article and Find Full Text PDF

Similarity of Biological Information Captured by Ga-PSMA-11 PET and ASL Perfusion MRI in Glioblastoma.

AJNR Am J Neuroradiol

August 2025

From the Department of Nuclear Medicine (Y.H., Z.C., J.L., Y.L.), Department of Magnetic Resonance (W.H., X.G., J.Z.), Department of Radiotherapy (X.C.), Department of Pathology (Y.S., Y.P.), Department of Neurosurgery (J.D., Z.G.), Gansu Province Clinical Research Center for Functional and Molecula

Background And Purpose: To further elucidate the potential biological mechanisms underlying the uptake of PSMA-targeted radioligands in glioblastoma (GBM) and to clarify the value of prostate-specific membrane antigen (PSMA) PET in characterizing the spatial heterogeneity of GBM microvascular distribution, this study aims to investigate the relationship between Ga-PSMA-11 PET and arterial spin-labeling (ASL) perfusion imaging, as well as the correlation between PSMA tracer uptake and immunohistochemical microvascular indices.

Materials And Methods: Twenty-six patients with newly diagnosed or recurrent GBM who underwent conventional MRI, ASL and PSMA PET were prospectively enrolled. We investigated the correlation between the semi-quantitative parameters of ASL and PSMA PET.

View Article and Find Full Text PDF

Objective: The aim of this study was to evaluate the relationship between Galium-68 prostate-specific membrane antigen positron emission tomography combined with computed tomography (Ga-PSMA PET/CT) quantitative parameters and patient obesity, prostate-specific antigen (PSA) levels, and metastasis type in prostate cancer.

Methods: In the present study, we included 112 patients diagnosed with prostate cancer between 2020 and 2024. These patients underwent 8Ga-PSMA PET/CT imaging for staging purposes, with locoregional or distant metastasis detected in the imaging results.

View Article and Find Full Text PDF