98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923326 | PMC |
http://dx.doi.org/10.1007/s13139-024-00882-1 | DOI Listing |
J Urol
September 2025
Department of Urology, Austin Health, Melbourne, Victoria, Australia.
Purpose: Prostate-specific membrane antigen positron emission tomography (PSMA PET) is increasingly used to diagnose and stage prostate cancer. A PRIMARY score uses anatomical localization and uptake patterns to improve diagnostic accuracy. We evaluated the histopathology of patients with no uptake pattern (PRIMARY score 1) and the prevalence of intraductal carcinoma of the prostate (IDC-P) in this subset compared with those with an uptake pattern (PRIMARY score ≥ 2).
View Article and Find Full Text PDFJ Med Chem
September 2025
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
We designed and synthesized a novel type of PSMA radioligand incorporating (2, 3) β-branched aromatic α-amino acids within the linker segment of its structure. PET/CT imaging and biodistribution analysis revealed that β-branched aromatic α-amino acids modified PSMA radioligands could maintain or even improve tumor targeting while exhibiting a more rapid renal clearance rate than [Ga]Ga-. With average renal uptake of less than 10%ID/g, as opposed to 25%ID/g for [Ga]Ga-, this substantial decrease in renal accumulation translates to a significantly improved safety profile by minimizing nephrotoxic risks.
View Article and Find Full Text PDFMol Imaging Biol
September 2025
Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Purpose: While PSMA-targeted radioligand therapy (RLT) has shown remarkable efficacy for treating end-stage prostate cancer, the α-emitting RLT often results in severe salivary gland toxicity, limiting its use. Various strategies to mitigate this side effect have been attempted with limited success. Accordingly, this study introduced a new PSMA-targeting ligand with more favorable binding characteristics than the existing ligands.
View Article and Find Full Text PDFAJNR Am J Neuroradiol
August 2025
From the Department of Nuclear Medicine (Y.H., Z.C., J.L., Y.L.), Department of Magnetic Resonance (W.H., X.G., J.Z.), Department of Radiotherapy (X.C.), Department of Pathology (Y.S., Y.P.), Department of Neurosurgery (J.D., Z.G.), Gansu Province Clinical Research Center for Functional and Molecula
Background And Purpose: To further elucidate the potential biological mechanisms underlying the uptake of PSMA-targeted radioligands in glioblastoma (GBM) and to clarify the value of prostate-specific membrane antigen (PSMA) PET in characterizing the spatial heterogeneity of GBM microvascular distribution, this study aims to investigate the relationship between Ga-PSMA-11 PET and arterial spin-labeling (ASL) perfusion imaging, as well as the correlation between PSMA tracer uptake and immunohistochemical microvascular indices.
Materials And Methods: Twenty-six patients with newly diagnosed or recurrent GBM who underwent conventional MRI, ASL and PSMA PET were prospectively enrolled. We investigated the correlation between the semi-quantitative parameters of ASL and PSMA PET.
Mol Imaging Radionucl Ther
August 2025
Sivas Cumhuriyet University Faculty of Medicine, Department of Nuclear Medicine, Sivas, Türkiye.
Objective: The aim of this study was to evaluate the relationship between Galium-68 prostate-specific membrane antigen positron emission tomography combined with computed tomography (Ga-PSMA PET/CT) quantitative parameters and patient obesity, prostate-specific antigen (PSA) levels, and metastasis type in prostate cancer.
Methods: In the present study, we included 112 patients diagnosed with prostate cancer between 2020 and 2024. These patients underwent 8Ga-PSMA PET/CT imaging for staging purposes, with locoregional or distant metastasis detected in the imaging results.