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Growth curve modeling has been widely used in many disciplines to understand the trajectories of growth. Two popular forms utilized in the real-world analyses are the linear and quadratic growth curve models. These models operate on the assumption that measurements are conducted exactly at pre-set time or intervals. In essence, the reliability of these models is deeply tied to the punctuality and consistency of the data collection process. However, in real-world data collection, this assumption is often violated. Deviations from the ideal measurement schedule often emerge, resulting in measurement error in time and consequent biased responses. Our simulation findings indicate that such error can skew estimations, especially in quadratic GCM. To account for the measurement error in time, we introduce a Bayesian growth curve model to accommodate the error in the individual time values. We demonstrate the performance of the proposed approach through simulation studies. Furthermore, to illustrate its application in practice, we provide a real-data example, underscoring the practical benefits of the proposed model.
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http://dx.doi.org/10.1080/00273171.2025.2473937 | DOI Listing |
Int J Womens Health
September 2025
Department of Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
Objective: This study aimed to assess the predictive capacity of placenta growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) levels in the serum of pregnant women during early pregnancy (11-13 weeks) for fetal growth restriction (FGR).
Patients And Methods: A retrospective cohort study was conducted involving 1602 pregnant women who gave birth at The Second Nanning People's Hospital between March 2018 and September 2019. Serum concentrations of PlGF and PAPP-A were measured during early pregnancy for all participants.
Front Physiol
August 2025
Department of Ultrasound, Deyang People's Hospital, Deyang, Sichuan, China.
Background: Antiphospholipid syndrome (APS) is a major immune-related disorder that leads to adverse pregnancy outcomes (APO), including recurrent miscarriage, placental abruption, preterm birth, and fetal growth restriction. Antiphospholipid antibodies (aPLs), particularly anticardiolipin antibodies (aCL), anti-β2-glycoprotein I antibodies (aβ2GP1), and lupus anticoagulant (LA), are considered key biomarkers for APS and are closely associated with adverse pregnancy outcomes. This is a prospective observational cohort study to use machine learning model to predict adverse pregnancy outcomes in APS patients using early pregnancy aPL levels and clinical features.
View Article and Find Full Text PDFNPJ Antimicrob Resist
September 2025
Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Studying how antibacterials operate at subinhibitory concentrations reveals how they impede normal growth. While previous works demonstrated drugs can impact multiple aspects of growth, such as prolonging the doubling time or reducing the maximal bacterial load, a systematic understanding of this phenomenon is lacking. It remains unknown if common principles dictate how drugs interfere with growth.
View Article and Find Full Text PDFBioresour Technol
September 2025
College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, People's Republic of China; Key Laboratory of Deep Processing and Safety Control for Specialty Agricultural Products in Guangxi Universities, Education Department of Guangxi Zhuang Autonomous Region, Nanning 530004,
This study investigated the inhibitory effect of sucrose on the autolysis of recombinant Bacillus subtilis WB600 during keratinase production and elucidated its mechanism. Growth curves, cell morphology observations, cell wall integrity detection, and transcriptome analysis revealed that 2 % sucrose significantly increased cell biomass and delayed autolysis. Keratinase activity reached 5670.
View Article and Find Full Text PDFInt J Pharm
September 2025
Department of Pharmacy, The First Hospital of China Medical University, Shenyang 110001, China. Electronic address:
Emodin is a natural anthraquinone derivative with poor water solubility, which limits its antibacterial activity. The purpose of this work is to investigate the antibacterial activity of emodin nanocrystals (EMD-NCs) with different particle sizes against Staphylococcus aureus (S. aureus) and explores its underlying mechanisms.
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