Structure-function insights of natural Ganoderma polysaccharides: advances in biosynthesis and functional food applications.

Nat Prod Bioprospect

State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.

Published: March 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Ganoderma polysaccharides (GPs), derived from various species of the Ganoderma genus, exhibit diverse bioactivities, including immune modulation, anti-tumor effects, and gut microbiota regulation. These properties position GPs as dual-purpose agents for medicinal and functional food development. This review comprehensively explores the structural complexity of six key GPs and their specific mechanisms of action, such as TLR signaling in immune modulation, apoptosis pathways in anti-tumor activity, and their prebiotic effects on gut microbiota. Additionally, the structure-activity relationships (SARs) of GPs are highlighted to elucidate their biological efficacy. Advances in green extraction techniques, including ultrasonic-assisted and enzymatic methods, are discussed for their roles in enhancing yield and aligning with sustainable production principles. Furthermore, the review addresses biotechnological innovations in polysaccharide biosynthesis, improving production efficiency and making large-scale production feasible. These insights, combined with ongoing research into their bioactivity, provide a solid foundation for developing health-promoting functional food products that incorporate GPs. Furthermore, future research directions are suggested to optimize biosynthesis pathways and fully harness the health benefits of these polysaccharides.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880470PMC
http://dx.doi.org/10.1007/s13659-025-00496-wDOI Listing

Publication Analysis

Top Keywords

functional food
12
ganoderma polysaccharides
8
immune modulation
8
effects gut
8
gut microbiota
8
gps
5
structure-function insights
4
insights natural
4
natural ganoderma
4
polysaccharides advances
4

Similar Publications

Degradation and ecological risk of a novel neonicotinoid insecticide imidaclothiz in aquatic environments: Kinetics, photodegradation and hydrolysis pathways, mechanism and metabolites toxicity evaluation.

Pestic Biochem Physiol

November 2025

Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri-food Quality Safety, School of Resource & Environment, Anhui Agricultural University, Hefei, Anhui 230036, China; Institute of Ecological Environmental Protection and Pollution Remediation Engineering, Anhui Agricultural U

Neonicotinoid insecticides residuals pose a threat to aquatic ecosystems and human health. Imidaclothiz, as a novel neonicotinoid pesticide, the metabolic mechanisms in aquatic environments was unclear. This study investigated the degradation characteristics of imidaclothiz in both pure and actual water, and analyzed the photodegradation and hydrolysis metabolites of imidaclothiz in aquatic environments and assessed their toxicity.

View Article and Find Full Text PDF

Comparison of the toxicity and pharmacological effects of two insecticides against the Asian corn borer, Ostrinia furnacalis.

Pestic Biochem Physiol

November 2025

Key Laboratory of Agri-Food Safety of Anhui Province, Anhui Agricultural University, Hefei 230036, China. Electronic address:

The Asian Corn Borer (ACB), Ostrinia furnacalis (Guenée) is a devastating pest of maize, causing significant yield and economic losses in Asia. GABA receptor inhibitors have served as effective tools for controlling ACB larvae over the past several decades. However, the toxicity levels and pharmacological properties of two insecticides, fluxametamide and fipronil against the ACB are still unclear.

View Article and Find Full Text PDF

Functional analysis of Sf-NPF1 in food intake and antifeedant induction by azadirachtin in Spodoptera frugiperda larvae.

Pestic Biochem Physiol

November 2025

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Azadirachtin, a highly effective botanical pesticide, demonstrated notable biological activities against Spodoptera frugiperda, including mortality induction, growth and development inhibition, and antifeedant effects. Neuropeptide F (NPF) has been shown to play a role in various physiological processes in insects. Nonetheless, the functions of Sf-NPF1 in regulating food intake and antifeedant induction by azadirachtin in S.

View Article and Find Full Text PDF

Mitochondria-targeted NIR fluorescent probe for detection of hydrogen sulfide and its application in monitoring food freshness and bioimaging.

Anal Chim Acta

November 2025

Jiangxi Provincial Key Laboratory of Organic Functional Molecules, Institute of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, 330013, PR China; Department of Ecology and Environment, Yuzhang Normal University, Nanchang, 330103, PR China. Electronic address: pushouzhi

Background: The hydrogen sulfide (HS) in spoilage of raw meat poses significant food safety risks to human health. Meanwhile, as a signaling molecule, HS is crucial for maintaining human physiological homeostasis. Thus, the establishment of an efficient method for HS detection is essential for safeguarding human health.

View Article and Find Full Text PDF

Chemically and Electromagnetically dual-enhanced COFs-Au@AgNPs SERS sensor integrated with deep learning for ultrasensitive detection of neonicotinoid pesticides.

Anal Chim Acta

November 2025

Measurement Technology & Instrumentation Key Laboratory of Hebei Province, Institute of Electrical Engineering, Yanshan University, Qinhuangdao, 066004, China.

Background: With the development of modern agriculture, neonicotinoid pesticides have been widely used due to their high efficiency and strong systemic properties. However, excessive use leads to the accumulation of residues in the food chain, threatening the ecosystem and human health. Pesticide residues are easily accumulated in oilseed crops and become concentrated during the edible oil refining process.

View Article and Find Full Text PDF