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Microbial consortium degradation technology can improve the degradation efficiency and adaptability through fungi-bacteria synergism, but the mechanism of the fungi-bacteria interaction is still unclear, making it difficult to optimize the degradation process. The microbial consortium J-6, with high lignin degradation efficiency and strong environmental adaptability, was obtained in our previous research. In this study, the fungi-bacteria interacting mechanism of the microbial consortium J-6 was inferred based on metabolomics technology. The results showed that the positive interaction between fungi and bacteria could improve the efficiency of lignin degradation. The metabolites released by fungi, especially betanidin and ergosterol, had an impact on bacterial metabolism, promoted the degradation of macromolecules, and significantly increased the lignin degradation efficiency. Metabolites released by bacteria, especially L-phenylalanine and taurine, played a key role in fungal metabolism, leading to more complete degradation. The interaction mechanism of chemical currencies exchange between fungi and bacteria during lignin degradation obtained in this study can provide theoretical guidance for microbial consortium degradation technology.
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http://dx.doi.org/10.3390/molecules30030508 | DOI Listing |
J Clin Periodontol
September 2025
Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany.
Background And Objective: Periodontitis is a chronic inflammatory disease driven by immune dysfunction and microbial imbalance. This study aims to identify circulating druggable proteins causally linked to the disease.
Materials And Methods: We integrated proteomics data from deCODE genetics with periodontitis genome-wide association studies (GWAS) from the Million Veteran Program to identify proteins associated with periodontitis.
Sci Rep
September 2025
Department of Environmental Science, Lahore College for Women University, Lahore, Pakistan.
Burning rice straw contribute to Atmospheric Pollution, which makes it unsustainable in the long-run, but are still opted by farmers due to faster removal of residue. Lignocellulose Degrading Microorganisms, facilitating sustainable management, may accelerate the breakdown of various crop residues. A study comprised of twenty-one treatments including fungal strains, bacterial strains and microbial consortia.
View Article and Find Full Text PDFACS Synth Biol
September 2025
Department of Systems Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 050-29, South Korea.
We report the development of a cofactor-free CO fixation platform based on a three-enzyme cascade comprising ferulic acid decarboxylase (AnFDC), phenylalanine ammonia-lyase (AvPAL), and l-amino acid deaminase (PmLAAD). Unlike canonical ATP- or NADPH-dependent CO assimilation pathways, this system uses a prFMN-dependent carboxylation mechanism, enabling efficient CO incorporation under ambient conditions without energy-intensive cofactors. Systematic screening identified AnFDC as the optimal decarboxylase for styrene carboxylation, while AvPAL and PmLAAD were selected for their superior catalytic efficiencies in the cascade.
View Article and Find Full Text PDFGut Microbes
December 2025
Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
Host - microbiome interactions are central to Crohn'sdisease (CD) pathogenesis; yet the early metabolic alterations that precededisease onset remain poorly defined. To explore preclinical metabolicsignatures of CD, we analyzed baseline serum metabolomic profiles in a nestedcase-control study within the Crohn's and Colitis Canada - Genetics, Environment, Microbiome (CCC-GEM) Project, a prospective cohort of 5,122 healthyfirst-degree relatives (FDRs) of CD patients. We included 78 individuals wholater developed CD and 311 matched FDRs who remained disease-free.
View Article and Find Full Text PDFCurr Microbiol
September 2025
Laboratorio de Biotecnología Microbiana, Universidad Nacional de Frontera, 20100, Sullana, Piura, Perú.
Peru is the eighth largest producer of cocoa beans worldwide; however, the high cadmium content (Cd) presented in the white Criollo cocoa beans from the Piura region, has limited their commercialization. A potential strategy to mitigate this problem is the application of native lactic acid bacteria (LAB), capable of reducing Cd during the fermentation stage of the grain. Three Theobroma cacao L.
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