Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Relapse of membranous nephropathy (MN) and other glomerular diseases has been observed after COVID-19 infection. The risk factors contributing to disease progression in MN patients after contracting COVID-19 remain unclear.
Methods: This retrospective study included 656 consecutive patients with biopsy-proven primary MN who received treatment and were regularly followed up for over six months. Logistic regression analyses were conducted to identify risk factors for disease progression.
Results: Among the cohort, 555 patients (84.6%) contracted COVID-19 from November 11th, 2022, to February 22nd, 2023. Of them, 112 patients (20.2%) experienced a > 50% increase in proteinuria, including 30 patients (5.4%) who experienced nephrotic syndrome relapse. Sixteen patients (2.9%) showed immune aggravation with elevated anti-PLA2R antibody levels, and five patients (0.9%) had immune relapse characterized by antibody reoccurrence. Kidney dysfunction, defined as an eGFR reduction > 30% from baseline, occurred in 10 patients (1.8%), with two patients (0.4%) progressing to ESKD. Four patients (0.7%) died of respiratory failure. Overall, 132 patients (24.0%) experienced disease progression after COVID-19 infection. Multivariate logistic regression identified longer fever duration (OR 1.118, 95% CI 1.029-1.356, P = 0.018), withdrawal of immunosuppressants and/or steroids (OR 2.571, 95% CI 1.377-4.799, P = 0.003) and extended drug cessation (OR 1.113, 95% CI 1.045-1.186, P = 0.001) as independent risk factors for MN progression.
Conclusions: These findings suggest prompt antiviral treatment and minimizing the duration of immunosuppressant withdrawal to optimize kidney outcomes in MN patients with COVID-19.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11817977 | PMC |
| http://dx.doi.org/10.1186/s12882-025-04000-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mobility impairment and fall concern predict wayfinding ability in persons with multiple sclerosis.
Mult Scler Relat Disord
September 2025
Department of Psychology, Wayne State University, Detroit, MI, 48202, USA; Institute of Gerontology, Wayne State University, Detroit, MI, 48202, USA; Translational Neuroscience Program, Wayne State University, Detroit, MI, 48201, USA. Electronic address:
The ability to navigate through one's environment is crucial for maintaining independence in daily life and depends on complex cognitive and motor functions that are vulnerable to decline in persons with Multiple Sclerosis (MS). While previous research suggests a role for mobility in the physical act of navigation, it remains unclear to what extent mobility impairment and perceptions of mobility constraints may modify wayfinding and the recall of environment details in support of successful navigation. Therefore, this study examined the relations among clinical mobility function, concern about falling, and recall of environment details in a clinical sample of MS.
View Article and Find Full Text PDFAge-related differences in the step-to-step control of foot placement during prolonged walking.
J Biomech
August 2025
Lampe Joint Department of Biomedical Engineering, UNC Chapel Hill & NC State University, Chapel Hill, NC, USA. Electronic address:
Walking is essential for maintaining independence and quality of life, yet aging may impair the neuromuscular function required for stable gait over time. This study sought to quantify age-related differences in step-to-step control during prolonged walking using detrended fluctuation analysis (DFA). We hypothesized that step-to-step changes in step length and step width would exhibit reduced temporal persistence over time, with more pronounced effects in older than in younger adults.
View Article and Find Full Text PDFArbuscular mycorrhizal fungi distribution responds to ecological damage characteristics in antimony mining ecosystems.
J Environ Manage
September 2025
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Science, Beijing, 100012, China.
The fragmented ecological environment in the mining ecosystem has a significant impact on the microbial community and affects ecosystem stability. Arbuscular mycorrhizal fungi (AMF) facilitate nutrient exchange and element cycling between soil and plants, which play a crucial role in the functionality and stability of soil ecosystems. However, the mechanism of ecological environment factors influencing AMF community assembly in mining areas is still unclear.
View Article and Find Full Text PDFThe Burden of Cancer and Precancerous Conditions Among Transgender Individuals in a Large Health Care Network: Retrospective Cohort Study.
JMIR Cancer
September 2025
Department of Health Outcomes and Biomedical Informatics, University of Florida, 1889 Museum Road, Suite 7000, Gainesville, FL, 32611, United States, 1 352 294-5969.
Background: Disparities in cancer burden between transgender and cisgender individuals remain an underexplored area of research.
Objective: This study aimed to examine the cumulative incidence and associated risk factors for cancer and precancerous conditions among transgender individuals compared with matched cisgender individuals.
Methods: We conducted a retrospective cohort study using patient-level electronic health record (EHR) data from the University of Florida Health Integrated Data Repository between 2012 and 2023.
Changes in Sarcopenia Status and Subsequent Cardiovascular Outcomes: Prospective Cohort Study.
JMIR Aging
September 2025
Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Sarcopenia is associated with cardiovascular diseases (CVDs). However, whether changes in sarcopenia status affect CVD risk remains unclear. In addition, how indoor fuel use impacts the sarcopenia transition process is less well studied.
View Article and Find Full Text PDF