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Compared with ordinary steels, stainless steels possess advantages such as robust corrosion resistance, beautiful appearance, and excellent ductility. This article investigated the performance of a novel C-shaped folded flange section stainless steel beam with web stiffeners under bending and shear interaction, with a focus on the effect of the web tension field on its performance after transverse constraint. Stiffeners can effectively promote the bearing capacity of cold-formed thin-wall components, and folded flanges are convenient for connecting to floors, thus expanding the application range of stainless steel components. This study detailed the three-point bending tests conducted on specimens with shear span ratios of 1.5 and 2, as well as the numerical analysis methods employed. The experimental results of ultimate bearing capacity were compared with the predictions made by the Direct Strength Method (DSM) and Continuous Strength Method (CSM) adopted in current design codes. It was found that positioning the stiffeners closer to the compression flange enhanced the bearing capacity of the member, and this enhancement effect became more pronounced with an increase in the shear span ratio. Furthermore, the Continuous Strength Method (CSM) predicts the moment and shear bearing capacity more accurately. Furthermore, the Continuous Strength Method (CSM) provided more precise predictions of both the bending moment and shear capacity under the web tension field. The research results are helpful to provide theoretical basis and technical support for such members in engineering applications.
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http://dx.doi.org/10.1038/s41598-025-89314-4 | DOI Listing |
J Hepatocell Carcinoma
September 2025
Department of Liver Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Objective: Anoikis is an anchorage-dependent programmed cell death implicated in multiple pathological processes of cancers; however, the prognostic value of anoikis-related genes (ANRGs) in hepatocellular carcinoma (HCC) remains unclear. Our study aims to develop an ANRGs-based prediction model to improve prognostic assessment in HCC patients.
Methods: The RNA-seq profile was performed to estimate the expression of ANRGs in HCC patients.
Med Eng Phys
October 2025
Centre for Simulation in Bioengineering, Biomechanics and Biomaterials (CS3B), Department of Mechanical Engineering, School of Engineering of Bauru, São Paulo State University (UNESP), Bauru, São Paulo, Brazil. Electronic address:
This study aimed to evaluate the near-cortical over-drilling technique on the mechanical behaviour of bone-plate constructs in a rabbit transverse femoral fracture. In vitro biomechanical testing and finite element (FE) models were used for analyses. Rabbits' bones (n = 14) were divided into two groups: G1 - without near-cortical over-drilling, and G2 - with near-cortical over-drilling.
View Article and Find Full Text PDFBioinspir Biomim
September 2025
Mechanical Intelligence (MI) Research Group, London South Bank University, 103 Borough Road, London, London, SE1 0AA, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Conventional rigid grippers remain the most-used robotic grippers in industrial assembly tasks. However, they are limited in their ability to handle a diverse range of objects. This study draws inspiration from nature to address these limitations, employing multidisciplinary methods, such as computer-aided design, parametric modeling, finite element analysis, 3D printing, and mechanical testing.
View Article and Find Full Text PDFVirology
September 2025
Infection Biology Unit, German Primate Center, 37077 Göttingen, Germany.
New SARS-CoV-2 variants continue to emerge and may cause new waves of COVID-19. Antibody evasion is a major driver of variant emergence but variants can also exhibit altered capacity to enter lung cells and to use ACE2 species orthologues for cell entry. Here, we assessed cell line tropism, usage of ACE2 orthologues and antibody evasion of variant MC.
View Article and Find Full Text PDFACS Nano
September 2025
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
Although traditional immunogenic cell death (ICD) inducers generate vaccines (ISV) to potentiate antiprogrammed cell death ligand 1 (anti-PDL1) antibodies therapy, their efficacy remains limited. This limitation may be attributed to the physical barrier created by extracellular matrix (ECM) and immunosuppressive metabolic barrier mediated by adenosine. Here, we report an oncolytic polymer (OP), a well-designed ε-polylysine derivative with ICD-inducing capacity, which can simultaneously facilitate the release of endogenous ECM-degrading enzyme, Cathepsin B.
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