Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Patients with chronic kidney disease (CKD) have an elevated risk of both vitamin D deficiency (VDD) and depression. However, the relationship between VDD and the risk of depression in this population remains unclear.
Methods: Using the TriNetX network database (2010-2019), we conducted a propensity score-matched cohort study of CKD patients aged ≥50 years. Patients were categorized into VDD (≤20 ng/mL) and control (≥30 ng/mL) groups based on measurements within 3 months of CKD diagnosis. The primary outcome was the incidence of major depression within 1 year of follow-up.
Results: Among 17,955 matched pairs, VDD was associated with increased depression risk at 1 year (hazard ratio [HR]: 1.929; 95% confidence interval [CI]: 1.52-2.448; < 0.0001). This association persisted through 3 years of follow-up. The relationship remained consistent across CKD stages, with similar risks in early (HR:1.977; 95% CI: 1.382-2.829) and CKD stage 3-5 (HR:1.981; 95% CI: 1.533-2.559). Males with VDD showed higher depression risk (HR: 2.264; 95% CI: 1.498-3.421) compared to females (HR:1.761; 95% CI: 1.307-2.374). Even vitamin D insufficiency (20-30 ng/mL) increased depression risk compared to normal levels (HR:1.667; 95% CI: 1.318-2.11). In patients with VDD, cerebrovascular disease, malnutrition, and ischemic heart disease are risk factors for depression.
Conclusion: VDD is independently associated with increased depression risk in patients with CKD, particularly in males. These findings suggest that maintaining adequate vitamin D levels might be important for mental health in patients with CKD, although randomized trials are needed to confirm whether supplementation can prevent depression in this population.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807813 | PMC |
| http://dx.doi.org/10.3389/fnut.2025.1540633 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring vitamin D profile of epiphytic lichen forming fungi in forest ecosystems: Influence of habitat-dependent ecological variables.
Fungal Biol
October 2025
Marmara Forestry Research Institute Directorate, Fatih Forest Campus, Maslak-Sarıyer, Istanbul, Türkiye.
Vitamin D is critically important for sustainable human health, and the rising prevalence of deficiency-related diseases has increased interest in natural sources. This study explores the potential of epiphytic lichen-forming fungi, known for their unique metabolites, as a novel biosource of vitamin D for pharmaceutical and nutraceutical applications. Fourteen epiphytic lichen species were collected using a stratified sampling method from four mountainous forests in the Marmara Region of Türkiye.
View Article and Find Full Text PDFBiofortification of tomatoes with beta-carotene through targeted gene editing.
Int J Biol Macromol
September 2025
Plant Biotechnology Research Center, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, School of Agriculture and Biology, Shanghai Jiao Tong University, Minhang, Shanghai, 200240, China. Electronic address:
Vitamin A deficiency is one of the most severe micronutrient-related health issues worldwide. Tomatoes, a widely cultivated crop for their adaptability, nutritional value, and lycopene content (a beta-carotene precursor), are ideal candidates for biofortification. In this study, CRISPR-mediated knockout mutants (cr-SlLCYe and cr-SlBCH) were generated to enhance the precursor supply to the β-carotene biosynthetic pathway and reduce its degradation.
View Article and Find Full Text PDFFolate status shows no relationship with vitamin B12 but reiterates the urgency for folate fortification in the UK.
Eur J Nutr
September 2025
Nutritional Biomarker Laboratory, MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Background: The UK has a high and increasing prevalence of folate deficiency. The decision to start mandatory folic acid fortification has not yet been implemented. Concern has been raised about the effect of high folate on vitamin B12 status.
View Article and Find Full Text PDFThe effect of hormonal contraceptives combined with vitamin D3 supplements on sexual dysfunction in women with polycystic ovary syndrome: a randomized double-blind placebo-controlled trial.
Arch Gynecol Obstet
September 2025
Department of Midwifery, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.
Background: Polycystic ovary syndrome (PCOS) is characterized by reproductive and endocrine abnormalities.
Objective: The present study aimed to assess the effect of oral contraceptive pills (OCPs) and vitamin D3 on sexual dysfunction in women with PCOS and vitamin D3 deficiency.
Materials And Methods: This randomized double-blind placebo-controlled clinical trial was conducted in Iran between January and April 2019.
Patients with vitamin D deficiency are more likely to develop complex region pain syndrome after extremity fractures: a large database propensity-matched cohort study.
Eur J Orthop Surg Traumatol
September 2025
University Hospitals of Cleveland, Cleveland, United States.
Purpose: The purpose of this study was to investigate the association between preexisting vitamin D deficiency and the development of complex regional pain syndrome (CRPS) in patients with isolated extremity fractures.
Methods: The TriNetX database was queried to identify patients aged 18 and older who experienced upper or lower extremity fractures. Two cohorts were created based on the presence of vitamin D deficiency.