Patients with vitamin D deficiency are more likely to develop complex region pain syndrome after extremity fractures: a large database propensity-matched cohort study.

Purpose: The purpose of this study was to investigate the association between preexisting vitamin D deficiency and the development of complex regional pain syndrome (CRPS) in patients with isolated extremity fractures.

Methods: The TriNetX database was queried to identify patients aged 18 and older who experienced upper or lower extremity fractures. Two cohorts were created based on the presence of vitamin D deficiency.

Multiplex Polymerase Chain Reaction vs Standard Urine Culture in Women Presenting with Symptoms of Acute Cystitis.

Introduction And Hypothesis: Prior studies suggest that acute cystitis diagnosis using standard urine culture (SUC) may be suboptimal compared to multiplex polymerase chain reaction (mPCR). mPCR is hypothesized to deliver faster and more accurate results.

Methods: This was a prospective, paired, within-subject study of female patients ≥ 60 years presenting with symptoms of acute cystitis.

Age-Related Changes in the Clinical Picture of Long COVID.

Background: This study evaluated the impact of aging on the frequency and prevalent symptoms of Long COVID, also termed post-acute sequelae of SARS-CoV-2, using a previously developed Long COVID research index (LCRI) of 41 self-reported symptoms in which those with 12 or more points were classified as likely to have Long COVID.

Methods: We analyzed community-dwelling participants ≥ 60 years old (2662 with prior infection, 461 controls) compared to participants 18-59 years (7549 infected, 728 controls) in the Researching COVID to Enhance Recovery adult (RECOVER-Adult) cohort ≥ 135 days post-onset.

Results: Compared to the Age 18-39 group, the adjusted odds of LCRI ≥ 12 were higher for the Age 40-49 group (odds ratio [OR] = 1.

Case Series of a Previously Undescribed Ulcerative Variant of Hidradenitis Suppurativa.

Introduction: Hidradenitis suppurativa (HS) is an auto-inflammatory disease characterized by recurrent painful nodules, abscesses, tunnels, and scarring, commonly seen in intertriginous body surfaces; however, an additional ulcerative phenotype has not been described and represents a specific clinical phenotype of the disease requiring special therapeutic considerations

Case Presentation: We report 4 patients with a previously undescribed, ulcerative phenotype of HS that did not respond to standard treatment but were healed with surgery. These lesions present as large, deep-dermal, erythematous, well-defined ulcers that are exquisitely tender.

Conclusion: This phenotype necessitates recognition by the clinician as a rapid path to combined pharmacologic and surgical management is crucial for the patient.

Clinical correlates of epilepsy self-management adherence among Hispanic people with epilepsy: Findings from the managing epilepsy well (MEW) network integrated database.

Background: Epilepsy self-management (ESM) by people living with epilepsy (PWE) can reduce seizure frequency and increase quality of life (QOL). ESM among Hispanic PWE is under-investigated and lacks adequate sampling and ESM assessment. The purpose of this study was to assess ESM and associated variables among Hispanic PWE using aggregate data from the Managing Epilepsy Well Network Integrated Database.

Evaluation and management of obstructive sleep apnea in adults hospitalized for medical care: an American Academy of Sleep Medicine clinical practice guideline.

Introduction: The purpose of this guideline is to establish clinical practice recommendations for the management of obstructive sleep apnea (OSA) in medically hospitalized adults.

Methods: The American Academy of Sleep Medicine (AASM) commissioned a task force of experts in sleep medicine to develop recommendations and assign strengths based on a systematic review of the literature and an assessment of the evidence using Grading of Recommendations, Assessment, Development and Evaluation methodology. The task force provided a summary of the relevant literature and the certainty of evidence, the balance of benefits and harms, patient values and preferences, and resource use considerations that support the recommendations.

Evaluation and management of obstructive sleep apnea in adults hospitalized for medical care: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.

Introduction: The purpose of this systematic review is to provide supporting evidence for a clinical practice guideline on management of obstructive sleep apnea in medically hospitalized adults.

Methods: The American Academy of Sleep Medicine commissioned a task force of experts in sleep medicine. A systematic review was conducted to identify randomized controlled trials and observational studies that addressed interventions for the management of obstructive sleep apnea in medically hospitalized adults.

Music Therapy in Patients Undergoing Pancreatic Surgery (MUSIC PUPS): A Mixed Methods Pilot Study.

Background: Pancreatoduodenectomy (PD) and distal pancreatectomy (DP) are painful procedures often accompanied by psychological distress. Music therapy interventions such as music-assisted relaxation and imagery (MARI) have demonstrated efficacy for acute pain but have not been examined within PD/DP. Gene expression mechanisms by which MARI may affect pain also remain poorly understood.

Treatment of central sleep apnea in adults: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.

Introduction: This systematic review provides supporting evidence for the accompanying clinical practice guideline on the treatment of central sleep apnea (CSA) syndrome in adults.

Methods: The American Academy of Sleep Medicine commissioned a task force of experts in sleep medicine. A systematic review was conducted to identify studies that compared the use of positive airway pressure therapies (PAP), non-PAP therapies, and pharmacological treatment to no treatment to improve patient-important outcomes.

Treatment of central sleep apnea in adults: an American Academy of Sleep Medicine clinical practice guideline.

Introduction: This guideline establishes clinical practice recommendations for treatment of central sleep apnea (CSA) syndromes in adults.

Methods: The American Academy of Sleep Medicine (AASM) commissioned a task force of experts in sleep medicine to develop recommendations and assign strengths based on a systematic review of the literature and an assessment of the evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. The task force provided a summary of the relevant literature and the certainty of evidence, the balance of benefits and harms, patient values and preferences, and resource use considerations that support the recommendations.

CD19 Directed CAR T Therapy for Transformed Follicular Lymphoma: A CIBMTR Analysis.

Transformed follicular lymphoma (tFL) is typically associated with chemotherapy resistance and a poor prognosis. There are limited data regarding outcomes after CD19-directed chimeric antigen receptor T-cell (CAR T) therapy in relapsed/refractory (R/R) tFL. A total of 923 adult patients with R/R tFL who received commercial CD19 CAR T therapy between 2017 and 2023 were identified in the Center for International Blood and Marrow Transplant Research registry.

Artificial intelligence in sleep medicine: an updated American Academy of Sleep Medicine position statement.

The field of artificial intelligence (AI) is rapidly expanding and has the potential to significantly impact the practice of sleep medicine. Sleep practitioners may be able to augment the efficiency and effectiveness of care delivery to patients by incorporating AI into clinical practice. However, AI must be implemented in a responsible manner, with a full appreciation of the technology's current limitations and evolving nature.

Acute Respiratory Distress Syndrome in Patients with Lymphopenia: Results from the National Inpatient Sample (2017-2021).

Lymphopenia has been associated with in-hospital, early, and late mortality. We aimed to elucidate differences in baseline characteristics in patients with lymphopenia with and without acute respiratory distress syndrome (ARDS) and determine predictors of in-hospital mortality in this patient population. Patients ≥ 18 years of age with lymphopenia were identified in the National Inpatient Sample (2017-2021) and stratified according to ARDS diagnosis.

Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort.

Background: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly after its identification in December 2019 to cause a global pandemic. The respiratory tract is the primary site of infection, and there is a large range in the severity of respiratory illnesses caused by the virus. Defining molecular and cellular factors for protection from severe disease and death has been a goal to better understand and to predict and mitigate the effects of SARS-CoV-2 and future coronaviruses.

Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study.

Introduction: The coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study collected clinical, demographic, blood cytometry, serum receptor-binding domain (RBD) antibody titers, metabolomics, targeted proteomics, nasal metagenomics, Olink, nasal viral load, autoantibody, SARS-CoV-2 antibody titers, and nasal and peripheral blood mononuclear cell (PBMC) transcriptomics data from patients hospitalized with COVID-19. The aim of this study is to select baseline biomarkers and build predictive models for 28-day in-hospital COVID-19 severity and mortality with most predictive variables while prioritizing routinely collected variables.

MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury.

MHC class I polypeptide-related sequence B (MICB) is a ligand for NKG2D. We have shown NK cells are central to lung transplant acute lung injury (ALI) via NKG2D activation, and increased MICB in bronchoalveolar lavage predicts ALI severity. Separately, we found a MICB polymorphism (MICBG406A) is associated with decreased ALI risk.

Clinical Delivery of Whole Systems Traditional Chinese Medicine and Impacts Upon Patient Reported Outcomes During IVF.

Background: Several clinical trials support the efficacy of Whole Systems Traditional Chinese Medicine (WS-TCM) modalities, including acupuncture, for improving outcomes among women undergoing in vitro fertilization (IVF), but few studies have described its real-world integration within an academic medical setting or its immediate effects on pain, stress, and anxiety.

Objective: To characterize the clinical delivery of WS-TCM and assess its effects on patient-reported outcomes (PROs) among patients receiving WS-TCM while undergoing IVF.

Methods: A retrospective review of patients who received ≥1 WS-TCM treatment associated with ≥1 embryo transfer at a single center was conducted.

Traumatic ulna fracture with plastic deformation of the radius in a skeletally mature pregnant female: a case report.

Case: A 20-year-old pregnant female presented with an ulna fracture after a crush and bending type injury. Anatomic reduction of her ulna was not possible due to plastic deformation of the radius, requiring a corrective osteotomy of the radius. She is now 16 months out from surgery with full painless range of motion and radiographic union.

Intermittent Hypoxemia and Neurodevelopmental Impairment at 12 and 24 Months in Preterm Infants.

Introduction: Neonatal studies have shown a relationship between intermittent hypoxemia (IH) and long-term sequelae although definitions of IH have varied. Employing multiple thresholds of IH and a wider gestational aged cohort of preterm infants, we hypothesized that increased IH exposure during the first month of life was associated with neurodevelopmental impairment (NDI) at 12 and 24 months corrected age.

Methods: IH (<80% or <90%) were documented from day of life 8 to 28 (n = 175 infants <31 weeks gestation).

High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19.

CD16A is an activating Fc receptor on NK cells that mediates antibody-dependent cellular cytotoxicity (ADCC), a key mechanism in antiviral immunity. However, the role of NK cell-mediated ADCC in SARS-CoV-2 infection remains unclear, particularly whether it limits viral spread and disease severity or contributes to the immunopathogenesis of COVID-19. We hypothesized that the high-affinity CD16AV176 polymorphism influences these outcomes.

Perceived Barriers to Medication Adherence in Adolescents and Young Adults with Attention-Deficit Hyperactivity Disorder: Adapting the Customized Adherence Enhancement Intervention.

Objective: Although the recommended first-line treatment for attention-deficit hyperactivity disorder (ADHD) is medication, poor adherence is still common, particularly in adolescents and young adults (AYAs). This study aimed to adapt Customized Adherence Enhancement (CAE), a psychosocial intervention developed to improve medication adherence in bipolar disorder, to target AYAs with ADHD.

Methods: Phase 1 included focus groups with AYAs, caregivers, and health care providers who treat AYAs with ADHD (N = 19).

The impact of white matter lesions on seizure recurrence after first epileptic seizures in the elderly: a prospective study.

Background: Despite considerable previous research, to what degree white matter lesions (WML) may be epileptogenic remains unclear. Therefore, the decision of initiating treatment with antiseizure medication (ASM) can be challenging in patients with only WML on neuroimaging. In this prospective study we assessed whether the prevalence, localization or severity of WML impact the risk of seizure recurrence in patients aged 60 years or older after first-time seizures.