98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763232 | PMC |
http://dx.doi.org/10.1016/j.cjco.2024.09.018 | DOI Listing |
Wounds
August 2025
Department of Nursing, Federal University of Ceará, Ceará, Brazil.
Background: Diabetic foot ulcers (DFUs) are a major clinical challenge, particularly among patients with refractory ulcers, that often lead to severe complications such as infection, amputation, and high mortality. Innovations supported by strong clinical evidence have the potential to improve healing outcomes, enhance quality of life, and reduce the economic burden on individuals and health care systems.
Objective: To describe the design of the concurrent optical and magnetic stimulation (COMS) therapy Investigational Device Exemption (IDE) study for refractory DFUs (MAVERICKS) trial.
Int J Antimicrob Agents
September 2025
Department of Pediatric Respiratory, Children's Medical Center, The First Hospital of Jilin University, Changchun, 130021, China. Electronic address:
The global proliferation of antibiotic-resistant Staphylococcus aureus, particularly methicillin-resistant Staphylococcus aureus (MRSA), highlights the urgent need for innovative antivirulence strategies. The redundancy and multiplicity of virulence factors produced by S. aureus necessitate interventions capable of concurrently targeting multiple virulence mechanisms.
View Article and Find Full Text PDFNat Prod Rep
September 2025
State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Covering: up to April 2025Bacterial aromatic polyketides represent a notable class of natural products that have found extensive applications in clinical treatments. In their biosynthesis, oxidative rearrangements represent critical transformations that typically afford diverse scaffolds, structural rigidity, and biological activities. In this context, it is evident that redox enzymes are frequently implicated in various rearrangement processes, whereby they facilitate the transformation of pathway precursors into mature natural products.
View Article and Find Full Text PDFComput Med Imaging Graph
August 2025
Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China. Electronic address:
Bipolar disorder (BD) is a debilitating mental illness characterized by significant mood swings, posing a substantial challenge for accurate diagnosis due to its clinical complexity. This paper presents CS2former, a novel approach leveraging a dual channel-spatial feature extraction module within a Transformer model to diagnose BD from resting-state functional MRI (Rs-fMRI) and T1-weighted MRI (T1w-MRI) data. CS2former employs a Channel-2D Spatial Feature Aggregation Module to decouple channel and spatial information from Rs-fMRI, while a Channel-3D Spatial Attention Module with Synchronized Attention Module (SAM) concurrently computes attention for T1w-MRI feature maps.
View Article and Find Full Text PDFJ Hazard Mater
September 2025
School of Ecology and Environment, Anhui Normal University, Wuhu, Anhui Province 241002, China; Collaborative Innovation Center of Recovery and Reconstruction of Degraded Ecosystem in Wanjiang Basin Co-Founded by Anhui Province and Ministry of Education, Wuhu, Anhui 241000, China. Electronic address
Tire wear particles (TWP) represent a significant source of marine microplastic pollution and have been shown to pose a considerable threat to marine organisms. In this study, the marine rotifer Brachionus plicatilis was employed as a model organism to systematically assess the effects of micron-sized and nano-sized TWP, as well as their leachates, on rotifer behavior, and underlying molecular mechanisms. The results revealed that TWP exposure significantly reduced rotifer motility, evidenced by decreased swimming speed and acceleration.
View Article and Find Full Text PDF