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Article Abstract
The circadian clock is an internal timekeeper system that regulates biological processes through a central circadian clock and peripheral clocks controlling various genes. Basic helix-loop-helix ARNT-like 1 (), also known as aryl hydrocarbon receptor nuclear translocator-like protein 1 (), is a key component of the circadian clock. The deletion of alone can abolish the circadian rhythms of the human body. plays a critical role in immune cell function. Dysregulation of is linked to immune-related diseases such as autoimmune diseases, infectious diseases, and cancer, and vice versa. This review highlights the significant role of in governing immune cells, including their development, differentiation, migration, homing, metabolism, and effector functions. This study also explores how dysregulation of can have far-reaching implications and potentially contribute to the onset of immune-related diseases such as autoimmune diseases, infectious diseases, cancer, sepsis, and trauma. Furthermore, this review discusses treatments for immune-related diseases that target disorders. Understanding the impact of on immune function can provide insights into the pathogenesis of immune-related diseases and help in the development of more effective treatment strategies. Targeting has been demonstrated to achieve good efficacy in immune-related diseases, indicating its promising potential as a targetable therapeutic target in these diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741524 | PMC |
| http://dx.doi.org/10.1093/burnst/tkae075 | DOI Listing |
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