G20 stroke burden 1990-2035: trends, projections and precision health insights.

Background: Stroke persists as the second leading global cause of mortality and disability. We analyzed G20 nations using Global Burden of Disease (GBD) 2021 data (1990-2021) to provide a new perspective.

Methods: We obtained age-standardized rates (ASR) of stroke mortality, incidence, prevalence, and YLLs (years of life lost) across G20 nations.

Uninfected cell-specific enzymes coordinate carbon supply and nitrogen assimilation in Medicago truncatula nodules.

In legume root nodules, rhizobia invade host cells to form symbiosomes that drive atmospheric nitrogen fixation. Although the metabolic roles of infected cells (ICs) are well established, the contributions of adjacent uninfected cells (UCs) have remained largely unexplored. Here, through forward genetics methods, we identify DEBINO4, a phosphoenolpyruvate carboxylase (PEPC) uniquely expressed in UCs, as a pivotal regulator of carbon metabolism essential for sustaining symbiosome function and nitrogen assimilation.

EEG-ERnet: Emotion Recognition based on Rhythmic EEG Convolutional Neural Network Model.

Background: Emotion recognition from electroencephalography (EEG) can play a pivotal role in the advancement of brain-computer interfaces (BCIs). Recent developments in deep learning, particularly convolutional neural networks (CNNs) and hybrid models, have significantly enhanced interest in this field. However, standard convolutional layers often conflate characteristics across various brain rhythms, complicating the identification of distinctive features vital for emotion recognition.

Research advances in SERS-based sensing platforms for multiplex mycotoxin detection in feed.

Mycotoxins in feed can pose significant risks to the health of livestock and poultry, leading to reduced economic returns and impaired production efficiency, thereby impeding the sustainable development of the livestock industry. Consequently, the exploration of highly sensitive, simple and rapid detection methods for trace mycotoxins in feed is crucial for ensuring feed safety and promoting industrial sustainability. Surface-enhanced Raman spectroscopy (SERS), a rapid detection method characterized by high sensitivity, ease of operation, and resistance to water interference, has gained substantial traction in mycotoxin detection within feed matrices in recent years.

Phosphorus(V) Tris(ethoxycarbonyl)corrole As a Safe and Effective Photosensitizer for Hepatocellular Carcinoma Treatment in Zebrafish Xenograft Models.

Corrole-based photosensitizers show great potential for tumor photodynamic therapy (PDT). While their photodynamic activity has been extensively studied at the cellular level, evaluation in mouse xenograft models remains challenging due to prolonged experimental timelines, complex drug administration, and high costs. To address these limitations, we developed a novel hepatocellular carcinoma model using wild-type AB zebrafish embryos as a xenograft platform.