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http://dx.doi.org/10.16288/j.yczz.24-194 | DOI Listing |
Plant Biotechnol J
September 2025
National key Laboratory for Development and Utilization of Forest Food Resources, International Research Center for Plant Cell Wall, College of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou, China.
Trends Biochem Sci
September 2025
Department of Biomedical Sciences, University of Padova, Padova, Italy; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM), Bari 70126, Italy. Electronic address:
The rise of AlphaFold and similar structure predictors has made it possible to determine the 3D structure of almost any protein from its amino acid sequence. Residue interaction networks (RINs), graphs where residues are represented as nodes and interactions as edges, provide a powerful framework for analyzing and interpreting this surge in structural data. Here, we provide a comprehensive introduction to RINs, exploring different approaches to constructing and analyzing them, including their integration with molecular dynamics (MD) simulations and artificial intelligence (AI).
View Article and Find Full Text PDFJ Biol Chem
September 2025
Department of Chemistry and Center for Molecular Signaling, Wake Forest University, Winston-Salem, NC, 27109. Electronic address:
The AUA isoleucine codon is generally rare and used with varying frequency in bacterial genomes. The tRNA responsible for decoding this trinucleotide must be modified at the wobble position by tRNA lysidine synthetase (TilS) prior to aminoacylation and accommodation at the ribosome. To test the hypothesis that TilS catalytic efficiency correlates with AUA frequency, we cloned tilS genes from bacteria with varying AUA codon usage.
View Article and Find Full Text PDFAdv Nutr
September 2025
Prevention Research Center, Stanford University School of Medicine, Stanford, CA, United States.
The sine qua non of intervention studies in general, and randomized controlled trials in particular, is to define and isolate an exposure of interest that defines the intervention and distinguishes between groups. The isolation of a presumptive cause is prerequisite to the confident attribution of given effects. In the context of dietary intervention studies, this has historically translated into a unitary intervention diet type, no matter the diversity of preferences, tastes, upbringings, ethnicities, and cultures represented in a given study cohort.
View Article and Find Full Text PDFStudy Question: Can patient age and ovarian reserve tests predict the number of cryopreserved oocytes in patients undergoing one or more ovarian stimulation cycles for elective oocyte cryopreservation (EOC)?
Summary Answer: A predictive model incorporating patient age, antral follicle count (AFC), anti-Müllerian hormone (AMH), and FSH levels achieved the greatest predictive accuracy.
What Is Known Already: As a consequence of societal evolution, women are increasingly delaying starting a family. However, the natural decline in ovarian reserve and oocyte quality as age advances can increase the risk of age-related fertility decline (ARFD) and involuntary childlessness.