Publications by authors named "Jorge B Dabdoub"
The AUA isoleucine codon is generally rare and used with varying frequency in bacterial genomes. The tRNA responsible for decoding this trinucleotide must be modified at the wobble position by tRNA lysidine synthetase (TilS) prior to aminoacylation and accommodation at the ribosome. To test the hypothesis that TilS catalytic efficiency correlates with AUA frequency, we cloned tilS genes from bacteria with varying AUA codon usage.
View Article and Find Full Text PDFDesigner membraneless organelles sequester native factors for control of cell behavior.
Nat Chem Biol
September 2021
Article Synopsis
- Synthetic membraneless organelles are designed to regulate biochemical reactions by compartmentalizing macromolecules, preventing interference, and allowing efficient information flow in cells.
- Researchers created a protein scaffold that assembles micron-sized condensates to sequester and insulate native proteins, enhancing cellular control.
- By relocalizing enzymes to these condensates and enabling controlled release, they can manipulate cellular activities such as proliferation and division, offering versatile applications for cellular engineering.