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Thymic malignant neoplasms mostly occur in the anterior mediastinum. Less than 5% occur in the middle or posterior mediastinum. This report describes a large subcarinal mass incidentally discovered during follow-up magnetic resonance imaging for prostate cancer operation. After multidisciplinary discussion, chemotherapy was deemed ineffective, and complete tumor resection through right posterolateral thoracotomy was performed. The operation was uneventful, and the patient recovered smoothly. Immunohistochemistry and pathologic examination revealed thymic adenocarcinoma. Although very rare, thymic adenocarcinomas should be considered in the differential diagnosis of middle mediastinal masses.
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http://dx.doi.org/10.1016/j.atssr.2023.02.017 | DOI Listing |
Cancer Rep (Hoboken)
September 2025
Department of Oncology, Eastern Health, Melbourne, Australia.
Background: Enteric-type thymic adenocarcinomas are an extremely rare and distinct subtype of thymic malignancies, as classified by the 2021 World Health Organization classification of thymic tumors. These tumors exhibit close molecular and morphologic similarity to primary gastrointestinal malignancies. To date, there are no tailored treatment guidelines for enteric-type thymic adenocarcinoma.
View Article and Find Full Text PDFMed Sci (Basel)
July 2025
Department of Surgical Sciences, Uppsala University, 752 36 Uppsala, Sweden.
: Atypical carcinoid of the thymus is an exceptionally rare neuroendocrine tumor originating from neuroendocrine cells within the thymus. These tumors often present with no symptoms or with nonspecific clinical signs, making early diagnosis particularly challenging. Despite their rarity, atypical carcinoids are clinically significant due to their aggressive nature and relatively poor prognosis.
View Article and Find Full Text PDFJ Surg Case Rep
July 2025
Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, 461 Bayi Avenue, Nanchang City, Jiangxi Province, 330006, China.
Thymic mucinous adenocarcinoma is an extremely rare and aggressive malignant tumor of the thymus with a very low 5-year survival rate. Here, we report a case of surgically resected primary mucinous adenocarcinoma of the thymus in a patient in his 60s who was admitted to the hospital with chest tightness for 2 weeks. The patient underwent median sternotomy and thymectomy, including resection of the brachiocephalic vein and partial resection of the superior vena cava wall.
View Article and Find Full Text PDFNeoplasia
September 2025
Depatment of medical oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital (Fujian Branch of Fudan University Shanghai Cancer Center), Fuzhou, Fujian, PR China; Interdisciplinary institute for medical engineering, Fuzhou University, Fuzhou, Fujian, PR China; Departm
The role of thymic epithelial cells (TECs) in eliminating self-reactive T cells through the presentation of self-antigens is well-established. However, it remains unclear whether TECs can eliminate tumor-reactive CD8 T cells by presenting tumor antigens. In this study, we observed that CD73 Granzyme B peripheral activated CD8 T cells undergo apoptosis in the medullary region of the thymus in DEN-CCL-induced spontaneous HCC mice, but not in the naïve control group.
View Article and Find Full Text PDFIndian J Pathol Microbiol
May 2025
Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Thymic malignancies are rare neoplasms, with thymoma and thymic carcinoma-collectively known as thymic epithelial tumors (TETs)-being uncommon tumors that originate from the thymus. Despite their rarity, TETs are the most prevalent tumors found in the anterior mediastinum of adults. The major histological types include squamous cell carcinoma, lymphoid epithelioid carcinoma, and basal-like carcinoma.
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