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http://dx.doi.org/10.1038/s41408-025-01210-2 | DOI Listing |
Antioxidants (Basel)
August 2025
Translational-Transdisciplinary Research Center, Medical Science Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea.
Intercellular mitochondrial transfer in the tumor microenvironment (TME) is a paradigm-shifting process that redefines cancer-T cell crosstalk. This review explores its dual nature as both a tumor immune evasion strategy and a promising therapeutic avenue. Crucially, oxidative stress acts as a key regulator, inducing tunneling nanotube (TNT) formation to facilitate this organelle exchange.
View Article and Find Full Text PDFAdv Sci (Weinh)
August 2025
Department of Women's and Children's Health, Onco-Hematology lab and clinic, University of Padova, Padova, 35128, Italy.
Mesenchymal stromal cells (MSCs) are key components of the tumor microenvironment (TME), influencing leukemia progression through poorly understood mechanisms. Here, the bioelectrical properties of MSCs derived from pediatric acute myeloid leukemia (AML) patients (AML-MSCs) are investigated, identifying a significant depolarization of their resting voltage membrane potential (V, -14.7 mV) compared to healthy MSCs (h-MSCs, -28.
View Article and Find Full Text PDFJ Nanobiotechnology
August 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaa
Mesenchymal stromal cells (MSCs) have shown promise in treating various diseases, and optimizing their therapeutic potential is a crucial objective in MSCs-based clinical applications. The microenvironment, particularly three-dimensional (3D) culture systems, plays a pivotal role in regulating the fate determination and enhancing the therapeutic potential of MSCs. Currently, the mechanisms governing the interactions between MSCs cultured in a dynamic 3D system and host recipient cells remain incompletely understood.
View Article and Find Full Text PDFAgeing Res Rev
August 2025
Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Medical Technology, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address:
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuronal degeneration and pathological α-synuclein accumulation. Mitochondrial dysfunction is a central feature in PD pathogenesis, contributing to impaired bioenergetics, oxidative stress, neuroinflammation, and defective organelle communication. This review synthesizes the current understanding of mitochondrial quality control mechanisms, including fission, fusion, mitophagy, and biogenesis, and their disruption in PD.
View Article and Find Full Text PDFFront Immunol
August 2025
Department of Clinical Laboratory, First Affiliated Hospital of Jilin University, Changchun, China.
Background: Mitochondrial transfer, the intercellular transmission of mitochondria via tunneling nanotubes(TNTs), extracellular vesicles(Evs), or cell fusion, has emerged as a critical mechanism in cancer progression. Increasing evidence suggests that this phenomenon not only supports tumor cell metabolism and drug resistance but also contributes to immune evasion, a hallmark of cancer.
Objective: This study aims to systematically explore the intellectual structure, research hotspots, and emerging trends of mitochondrial transfer in tumor immune evasion using bibliometric and visualization tools.