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Bearings are critical in mechanical systems, as their health impacts system reliability. Proactive monitoring and diagnosing of bearing faults can prevent significant safety issues. Among various diagnostic methods that analyze bearing vibration signals, deep learning is notably effective. However, bearings often operate in noisy environments, especially during failures, which poses a challenge to most current deep learning methods that assume noise-free data. Therefore, this paper designs a Multi-Location Multi-Scale Multi-Level Information Attention Activation Network (MLSCA-CW) with excellent performance in different kinds of strong noise environments by combining soft threshold, self-activation, and self-attention mechanisms. The model has enhanced filtering performance and multi-location information fusion ability. Our comparative and ablation experiments demonstrate that the model's components, including the multi-location and multi-scale vibration extraction module, soft threshold noise filtering module, multi-scale self-activation mechanism, and layer attention mechanism, are highly effective in filtering noise from various locations and extracting multi-dimensional features. The MLSCA-CW model achieves 92.02% accuracy against various strong noise disturbance and outperforms SOTA methods under challenging working conditions in CWRU dataset.
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http://dx.doi.org/10.1038/s41598-025-85275-w | DOI Listing |
Med Int (Lond)
August 2025
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
Punicalagin, a polyphenolic compound extracted from pomegranate peel, has received increasing attention in recent years due to its antibacterial and antiviral properties. Punicalagin is capable of inhibiting bacterial growth at sub-inhibitory concentrations by affecting cell membrane formation, disrupting membrane integrity, altering cell permeability, affecting efflux pumps, interfering with quorum sensing and influencing virulence factors. Additionally, punicalagin inhibits viruses by modulating enzyme activity, interacting with viral surface proteins, affecting gene expression, blocking viral attachment, disrupting virus receptor interaction and inhibiting viral replication.
View Article and Find Full Text PDFJ Healthc Sci Humanit
January 2024
Program Manager, Center for Biomedical Research/Research Centers in Minority Institutions (TU CBR/RCMI), Department of Biology, College of Arts and Sciences (CAS), Tuskegee University, Phone: (334) 724-4391, Email:
The emergence of the Novel COVID-19 Pandemic has undoubtedly impacted the lives of individuals across the globe. It has drawn the attention of major public health agencies as they work intensely towards understanding the behavior of the virus causing the disease, while simultaneously establishing ways to curb the spread of the virus among populations. As of the time of writing, 7,949,973 confirmed cases have been reported globally; with the United States (US) contributing to 26.
View Article and Find Full Text PDFMol Ther Methods Clin Dev
September 2025
Office of Gene Therapy, Office of Therapeutic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.
genome editing with CRISPR-Cas9 systems is generating worldwide attention and enthusiasm for the possible treatment of genetic disorders. However, the consequences of potential immunogenicity of the bacterial Cas9 protein and the AAV capsid have been the subject of considerable debate. Here, we model the antigen presentation in cells after gene editing by transduction of a human cell line with an AAV2 vector that delivers the Cas9 transgene.
View Article and Find Full Text PDFBeilstein J Nanotechnol
August 2025
Department of Physics & Engineering Physics, Morgan State University, Baltimore, MD 21251, USA.
Nanoscale biosensors have gained attention in recent years due to their unique characteristics and size. Manufacturing steps, cost, and other shortcomings limit the widespread use and commercialization of nanoscale electrodes. In this work, a nano-size electrode fabricated by directed electrochemical nanowire assembly and parylene-C insulation is introduced.
View Article and Find Full Text PDFRSC Adv
September 2025
Department of Medicinal Chemistry, Faculty of Pharmacy, Galala University P. O. 43713 New Galala Egypt
Isatin (1-indole-2,3-dione) is a privileged nitrogen-containing heterocyclic framework that has received considerable attention in anticancer drug discovery owing to its general biological behavior and structural diversity. This review focuses on isatin-heterocyclic hybrids as a valuable model in the development of new anti-cancer drugs that may reduce side effects and help overcome drug resistance, discussing their synthetic approaches and mechanism of action as apoptosis induction through kinase inhibition. With various chemical modifications, isatin had an excellent ability to build powerful isatin hybrids and conjugates targeting multiple oncogenic pathways.
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