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Additive manufacturing (AM) techniques have the potential to produce complex parts, and many of these techniques require the use of support structures to prevent deformations and to minimize thermal effects during the printing process, particularly when building overhangs and internal cavities. However, removing the support structures through postprocessing incurs additional costs and time penalties. Unlike other AM techniques, support structures are not used in directed energy deposition (DED) technique due to its working principle. Therefore, special multiaxis complex path-planning strategies for DED are adopted to print relatively simple overhang geometries. Nevertheless, printing internal channels using this technique can still be challenging or nearly impossible. In this work, a novel DED process using graphite as a support material is proposed for additively manufacturing simple and complex internal channels. The support material is easily removed without requiring extensive machining processes. The results demonstrated that the support material did not negatively impact part quality, and in fact, the presence of different carbides at the interaction zone increased hardness and Young's modulus. Moreover, there were no cracks and or porosity at the support material-part interface. This study is the first of its kind to demonstrate the potential for using graphite as a support material for DED processes in additively manufacturing parts with complex internal channels and overhangs and highlights the need for further research in this area.
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http://dx.doi.org/10.1089/3dp.2023.0057 | DOI Listing |
Anal Chem
September 2025
Department of Chemistry, Wuhan University, Wuhan 430072, China.
Three-dimensional printing (3DP) technology enables the flexible fabrication of integrated monolithic microextraction chips for high-throughput sample pretreatment. Meanwhile, the extraction performance of 3DP-based channels is largely limited by printer resolution and the commercially available printing materials. In this work, a 3DP array monolithic microextraction chip (AMC) was fabricated by integrating 26-array helical monolithic microextraction channels for sample pretreatment and 52-array gas valves for fluid control.
View Article and Find Full Text PDFJ Org Chem
September 2025
National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, P. R. China.
We herein describe a novel decarboxylation/cyclization sequence involving a three-component reaction of dialkyl 2-(alkoxymethylene)malonate, amines, and terminal alkyne ester or internal alkyne ester catalyzed by CsCO under microwave conditions. These two types of highly chemo- and regioselective transformations were accomplished by different reaction channels to furnish a wide range of functionalized 8-hydroxyisoquinoline-1(2)-ones (21 examples) and 2-pyridones (18 examples) in good to excellent yields and might provide new opportunities for the discovery of N-heterocyclic drugs and other functional molecules.
View Article and Find Full Text PDFHealth Promot Pract
September 2025
Center for Nutrition & Health Impact, Omaha, NE, USA.
The U.S. foundations contribute billions of dollars each year to community-based organizations (CBOs).
View Article and Find Full Text PDFClin Exp Nephrol
September 2025
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Background: Sacubitril/valsartan is typically prescribed for patients with heart failure and hypertension. We previously reported that sacubitril/valsartan provides comparable blood pressure (BP) reduction and superior tolerability compared to thiazide diuretics. This post hoc study aimed to compare the effects of sacubitril/valsartan and thiazide diuretics in patients with chronic kidney disease (CKD).
View Article and Find Full Text PDFThe Ordos Basin's Hangjinqi Shiligahan west zone Xiashihezi Formation 1 Member gas reservoir exhibits significant exploration and development potential. However, its sedimentation and reservoir characteristics are poorly understood. To address this, geological, seismic, macroscopic, and microscopic methods are combined.
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