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Objective: In the loop technique for mitral valve repair, the loop bundles are usually created during cardiac arrest after chordal length measurements, which seems time-consuming and less reproducible. To address this issue, we determined the loop length preoperatively using 4-dimensional computed tomography.
Methods: The loop length was determined on the basis of the distance from the papillary muscle head to the free margin of nonprolapsing leaflet corresponding to the prolapsed leaflet, to which the loops would be secured. Measurements were made on the commissural and long-axis views created by a medical image post-processor in the late systolic phase. This technique was used in consecutive 45 patients undergoing mitral valve repair with the loop technique since April 2021.
Results: A total of 55 loop bundles were created in 45 patients; in 10 cases loop bundles were fixed to both anterior and posterior papillary muscles. There were 31 posterior, 6 anterior, and 8 bileaflet prolapse. The loop length was set at 16 to 26 mm (median 19 mm). Mitral valve repair was successfully completed in all patients, and the loop bundles of predetermined length were used successfully in 42 patients (93.3%). Postoperative echocardiography revealed none/trace regurgitation in 41 and mild regurgitation in 4. There was no hospital mortality or major postoperative complication. During 4 to 35 months follow-up (median 10 months), no case required reintervention for the mitral valve.
Conclusions: Preoperative measurements using 4-dimensional computed tomography can accurately and reproducibly predict the required loop length for mitral valve repair.
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http://dx.doi.org/10.1016/j.xjtc.2024.08.021 | DOI Listing |
FASEB Bioadv
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Kobilka Institute of Innovative Drug Discovery, School of Medicine The Chinese University of Hong Kong Shenzhen Guangdong China.
Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor (GPCR) that mediates chemotaxis and bactericidal activities in phagocytes. The monoclonal antibody 5F1 is generated against full-length FPR1 and used widely for detection of FPR1 expression. This study aimed to characterize 5F1 for its functions.
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September 2025
Institute for Evidence in Medicine, Medical Center - University of Freiburg / Medical Faculty - University of Freiburg, Freiburg, Germany.
Rationale: Cervical cancer is the fourth most common cancer affecting women worldwide, caused by persistent infection with oncogenic human papillomavirus (HPV) types. While HPV infections usually resolve spontaneously, persistent infections with high-risk HPV types can progress to premalignant glandular or - mostly - squamous intraepithelial lesions, usually classified in cervical intraepithelial neoplasia (CIN). Women with CIN 2 and CIN 3 (i.
View Article and Find Full Text PDFAdv Mater
September 2025
Department of Mechanical Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.
Polyesters, with their tunable chemical structures and environmental sustainability, have drawn growing attention as solid polymer electrolytes for next-generation solid-state lithium metal batteries (SSLMBs). Through a comprehensive experimental and theoretical study involving the systematic variation of carbon chain lengths in the flexible (diol) and coordinating (diacid) segments, along with selective fluorination at distinct positions along the polymer backbone, 18 types of polyester are fabricated and demonstrate that fluorination at the coordinating segment significantly enhances ionic conductivity by suppressing crystallinity. In contrast, fluorination at the flexible segment reduces ionic migration barriers by providing more homogeneous coordinating sites, thereby improving the lithium-ion transference number, despite increasing chain rigidity and a reduction in overall ionic conductivity.
View Article and Find Full Text PDFFungal Biol
October 2025
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Electronic address:
In many model organisms, the circadian system has been proposed to comprise multiple oscillators that interact to promote accuracy of the clock as well as intricacies of rhythmic outputs. In Neurospora crassa, the circadian transcriptional/translational loop comprising of the FRQ (Frequency) and WCC (White Collar Complex) proteins has been instrumental in explaining many attributes of the clock including entrainment and rhythms in development and gene expression; in addition, some non-circadian oscillations can be unmasked when the FRQ-WCC feedback loop is eliminated. These rhythms have often lost defining circadian characteristics and are potentially controlled by other oscillators, termed FRQ-less oscillators (FLOs) in Neurospora.
View Article and Find Full Text PDFPlanta
September 2025
Department of Life Sciences, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju, 54896, Jeonbuk State, Korea.
PHYTOCHROME INTERACTING FACTOR4 (PIF4) plays an important role in regulating plant thermomorphogenesis. In this study, two PIF4 homologous genes, BcPIF4-1 and BcPIF4-2 (Brassica rapa subsp. CHINENSIS PIF4-1 and PIF4-2), were investigated.
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