Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background/objective: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) lack effective therapies. There is no consensus or guidance on which endpoints or outcome measures should be used in clinical trials. This study aimed to develop a core outcome set aligned with both patient and provider priorities for RAP and CP. Utilizing the Outcomes Measures in Rheumatology (OMERACT) framework, a multi-stakeholder approach was adopted to identify and prioritize outcome domains.
Methods: A two-round Delphi poll was conducted among four stakeholder groups: adult patients, parents and pediatric patients, adult health care providers and pediatric health care providers. Steering committee consensus further refined the core outcome domains, categorizing them as mandatory, important but optional, or research agenda domains, with full consensus achieved.
Results: Pain severity, ability to participate in social roles and activities, pancreatitis related hospitalization/ER visits and acute pancreatitis flare-ups were recommended as mandatory outcome domains for future clinical trials in RAP/CP.
Conclusions: Using the OMERACT framework, we developed a core outcome set for RAP and CP. Future research will focus on identifying validated measures for each domain, facilitating standardized assessments across clinical trials.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648530 | PMC |
| http://dx.doi.org/10.1016/j.pan.2024.11.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Drug-Eluting Resorbable Scaffold Versus Balloon Angioplasty for Below-the-Knee Peripheral Artery Disease: 2-Year Results From the LIFE-BTK Trial.
Circulation
September 2025
Division of Cardiology, Columbia University Irving Medical Center, New York, NY (S.A.P.).
Background: Limited treatment options exist for infrapopliteal disease in patients with chronic limb-threatening ischemia (CLTI), a condition associated with a high risk of limb loss. Interventional management of diseased infrapopliteal vessels with percutaneous transluminal angioplasty (PTA) is associated with high rates of restenosis and reintervention. In the LIFE-BTK trial, the drug-eluting resorbable scaffold (DRS) demonstrated superior 12-month efficacy compared with PTA in a selected CLTI population with predominantly noncomplex, mildly to moderately calcified lesions.
View Article and Find Full Text PDFPioneering the IBD specialist nurse role in China: a shared decision-making model for clinical practice innovation.
Front Med (Lausanne)
August 2025
Department of Nursing, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Inflammatory bowel disease (IBD) is a chronic condition characterized by the need for highly individualized treatment plans, requiring patients to make numerous complex medical decisions. Shared decision-making (SDM) has proven effective in improving treatment outcomes, patient satisfaction, and adherence in IBD management; however, its clinical implementation remains challenging. In China, formal SDM nurse roles have not yet been established.
View Article and Find Full Text PDFThe effects of circadian rhythm on reproductive functions.
Zygote
September 2025
International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Circadian rhythms are intrinsic, endogenously generated cycles that regulate various physiological processes, including reproductive functions. These rhythms are orchestrated by a network of core clock genes and are influenced by external environmental cues, primarily the light-dark cycle. Disruptions in circadian rhythms can have profound effects on fertility in both males and females, impacting processes such as the estrous cycle, ovulation, sperm production, implantation and pregnancy maintenance.
View Article and Find Full Text PDFWGCNA and LASSO regression-based selection and validation of microRNA biomarkers of β-thalassemia.
Blood Cells Mol Dis
September 2025
NHC Key Laboratory of Thalassemia Medicine, The First Afliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; Guangxi Key Laboratory of Thalassemia Research, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, China. Electronic address:
Objective: In patients with severe β-thalassemia, fetal hemoglobin (HbF) upregulation may provide an avenue to better therapeutic outcomes. The mechanisms that regulate the expression of HbF, however, are currently unclear. This study was developed with the goal of exploring biomarkers and molecular mechanisms associated with HbF expression to help inform the development of novel therapeutic strategies.
View Article and Find Full Text PDFInfluence of obesity and socio-linguistic factors on otitis externa treatment outcomes in children.
Int J Pediatr Otorhinolaryngol
August 2025
Children's Hospital Los Angeles Division of Otolaryngology - Head and Neck Surgery, 4650 Sunset Blvd., Los Angeles, CA, 90027, USA; Caruso Department of Otolaryngology - Head & Neck Surgery, Keck School of Medicine of the University of Southern California, 1500 San Pablo St, Los Angeles, CA, 90033,
Background: Established risk factors for the development of otitis externa (OE) include stenotic ear canals, dermatologic disease and insertion of foreign objects. The link between obesity and susceptibility to different systemic diseases have been demonstrated, but not yet with OE.
Objective: This study was aimed at determining whether obese patients had OE infections that were more difficult to treat compared to normal weight children and investigate other measurable patient factors contributing to OE infection resolution in our unique patient population.