Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Natural bioactive compounds have become increasingly important antitumor and antimicrobial agents due to their high therapeutic potential and low systemic toxicity. However, they also have significant drawbacks like nontumor targeting and low bioavailability, which limit their wide therapeutic applications. There is an urgent need for a safe and compatible nanoparticle-mediated drug delivery system for the efficient transport of drug candidates into tumor tissues. In this paper, amine-modified zinc oxide nanoparticles are synthesized to load luteolin. The functionalized nanoparticles exhibit good synergistic effects in terms of antitumor and antibacterial activities. They show significant induction of oxidative stress and antitumor effects, while no significant inhibitory effect on normal cells is observed, suggesting that the nanocomposites have good targeting of cancer cells. Autophagy activation and EMT inhibition effects are studied to explain the good antitumor performances. The prepared nanocomposites are demonstrated to be attractive candidates for cancer therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.langmuir.4c04194 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Involvement of Ductal Reaction in Di-(2-ethylhexyl)-Phthalate-Caused Hepatic Fibrosis: Molecular Mechanisms and Potential Intervention Strategies.
Chem Biol Interact
September 2025
Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address:
Di-(2-ethylhexyl)-phthalate (DEHP) is a persistent environmental endocrine toxicant present in many products, and liver is the main target organ for DEHP metabolism. Long-term exposure to DEHP induces hepatic fibrosis, which is reversible in the early stages, while progresses to cirrhosis without timely intervention. Ductular reaction (DR) is a characteristic pathological change in hepatobiliary diseases, however, the involvement of DR in DEHP-caused hepatic fibrosis, the underlying molecular mechanisms, remail largely uninvestigated.
View Article and Find Full Text PDFDiscovery of insect Fairmaire extracts with anti-tyrosinase activity and anti-melanin deposition.
Front Pharmacol
August 2025
Engineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, National Research Facility for Phenotypic
Background: Fairmaire is a medicinal insect that has been used for a long time by minority ethnic groups in Yunnan, China, due to its immunomodulatory function. However, its potential applications in cosmetics have not been reported.
Methods: experiments were used to verify whether the extracts of Fairmaire (EBR) have the effect of inhibiting TYR activity and eliminating melanin deposition.
" TPGS-Functionalized Nanocarriers with improved flavonoid oral bioavailability and therapeutic Action: Pharmacokinetic and Mechanistic Insights in Diabetes-Induced Retinopathy ".
Eur J Pharm Biopharm
September 2025
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Salman International University, Ras Sudr 46612, South Sinai, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt. Electronic address: mohamed.yehi
Diabetes mellitus is a metabolic disorder with escalating prevalence. It's a chief cause of microvascular complications, notably diabetic retinopathy (DR), which can predispose to permanent vision loss. Inflammation and oxidative stress are pivotal contributors to the progression of DR.
View Article and Find Full Text PDFExploring the mechanism of Danshen in treating Kawasaki disease through network pharmacology and molecular docking approaches.
Medicine (Baltimore)
August 2025
Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong Province, China.
This study aims to identify the primary active components of Danshen (Salvia miltiorrhiza) and explore the potential mechanisms underlying its therapeutic effect on Kawasaki disease (KD). Active components of Danshen and their action targets were screened using traditional Chinese medicine systems pharmacology and SwissTargetPrediction databases. KD-related targets were retrieved from Online Mendelian Inheritance in Man, Pharmacogenomics Knowledge Base, and GeneCards databases.
View Article and Find Full Text PDFFlavonoid biosynthesis facilitates low nitrogen adaptation in Gleditsia sinensis seedlings: Insights from comprehensive physiological and omics analyses.
Plant Physiol Biochem
August 2025
College of Forestry, Guizhou University, Guiyang, 550025, China; Institute for Forest Resources & Environment of Guizhou, Guizhou University, Guiyang, 550025, China; Key Laboratory of Forest Cultivation in Plateau Mountain of Guizhou Province, Guiyang, 550025, China.
Nitrogen (N) deficiency significantly constrains plant growth and the productivity of plantations. To elucidate the adaptation mechanisms of Gleditsia sinensis (G. sinensis) to low-N stress, an integrated analysis encompassing physiology, transcriptomics, and metabolomics was conducted on low-N tolerant (Changshun1, R) and sensitive (Luoting2, S) genotype seedlings.
View Article and Find Full Text PDF