98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599907 | PMC |
http://dx.doi.org/10.1111/phpp.13014 | DOI Listing |
Nat Aging
September 2025
Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Aging is a major risk factor for various neurological disorders, including Alzheimer's disease, and is associated with the accumulation of senescent cells, which can themselves propagate the senescence process through paracrine signaling. Migrasomes are organelles that form during cellular migration, detach from parent cells and mediate intercellular communication. Here we demonstrate that border-associated macrophages (BAMs) acquire senescence-associated properties during early brain aging, possibly due to prolonged exposure to amyloid beta.
View Article and Find Full Text PDFEnviron Sci Technol
September 2025
State Key Laboratory of Advanced Environmental Technology, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
The potential of PM to cause lung cancer has been well established; however, evidence regarding which specific components are responsible remains limited. We investigated dissolved organic matter (DOM) in PM using high-resolution mass spectrometry (HRMS) and cellular DNA damage assays to elucidate molecular composition and sources of carcinogenic components. Our analysis revealed hundreds of genotoxic compounds, with condensed aromatic amines predominating in number, abundance, and contribution to overall genotoxicity.
View Article and Find Full Text PDFBiomed Chromatogr
October 2025
College of Medicine, Lishui University, Lishui, China.
Saikosaponin A (SSa) is an oleanane type triterpenoid saponin isolated from Radix Bupleuri (Bupleurum chinense DC). While SSa has demonstrated significant pharmacological activities including anti-inflammatory, antioxidant, and antidepressant effects, its pharmacokinetic profile remains poorly characterized. This study developed and validated a sensitive LC-MS/MS method for quantifying SSa in rat plasma.
View Article and Find Full Text PDFJ Affect Disord
September 2025
Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Neurology, Yale University, New Haven, CT, USA. Electronic address:
Purpose: Dopamine is a neurotransmitter implicated in functions ranging from motor control to cognitive performance. In humans, dopaminergic markers have been associated with seasonal symptomatic fluctuations. Here we investigated potential seasonal variations in dopamine D2/D3 receptor availability in healthy adults using [C]PHNO positron emission tomography (PET) imaging.
View Article and Find Full Text PDFNeurochem Int
September 2025
Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China; Advanced Medical Technology Center, the First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China; Key La
General anesthetics are essential in pediatric medicine, yet concerns persist regarding their potential neurotoxic effects on the developing brain. Whether transient synaptic disruptions caused by anesthesia lead to long-term deficits or are mitigated by endogenous plasticity remains unresolved. Here, we use longitudinal in vivo two-photon imaging in awake mice to investigate the structural and functional consequences of a single, clinically relevant exposure to sevoflurane at postnatal day 20.
View Article and Find Full Text PDF