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Pleistocene Ice Ages display abrupt Dansgaard-Oeschger (DO) climate oscillations that provide prime examples of Earth System tipping points-abrupt transition that may result in irreversible change. Greenland ice cores provide key records of DO climate variability, but gas-calibrated estimates of the temperature change magnitudes have been limited to central and northwest Greenland. Here, we present ice-core δN-N records from south (Dye 3) and coastal east Greenland (Renland) to calibrate the local water isotope thermometer and provide a Greenland-wide spatial characterization of DO event magnitude. We combine these data with existing records of δO, deuterium excess, and accumulation rates to create a multiproxy "fingerprint" of the DO impact on Greenland. Isotope-enabled climate models have skill in simulating the observational multiproxy DO event impact, and we use a series of idealized simulations with such models to identify regions of the North Atlantic that are critical in explaining DO variability. Our experiments imply that wintertime sea ice variation in the subpolar gyre, rather than the commonly invoked Nordic Seas, is both a sufficient and a necessary condition to explain the observed DO impacts in Greenland, whatever the distal cause. Moisture-tagging experiments support the idea that Greenland DO isotope signals may be explained almost entirely via changes in the vapor source distribution and that site temperature is not a main control on δO during DO transitions, contrary to the traditional interpretation. Our results provide a comprehensive, multiproxy, data-model synthesis of abrupt DO climate variability in Greenland.
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http://dx.doi.org/10.1073/pnas.2402637121 | DOI Listing |
Eur Arch Psychiatry Clin Neurosci
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School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
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View Article and Find Full Text PDFAm J Respir Cell Mol Biol
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University of California Davis, Department of Internal Medicine, Davis, California, United States;
Int J Circumpolar Health
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Nord University, and the Members of the ArcSolution Project.
Unlabelled: There remains an unmet clinical need for improved treatment strategies in Acute Myeloid Leukemia (AML). Although radiopharmaceutical therapies targeting non-cancer-selective antigens have shown promise in AML, their clinical utility is often limited by prolonged bone marrow suppression. Using a unique proteomics-based strategy, we recently identified the active conformation of integrin-β2 (aITGB2) as a novel, tumor-selective target for AML.
View Article and Find Full Text PDFEBioMedicine
September 2025
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom; NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
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