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Leaf Area Index (LAI) is a critical parameter in terrestrial ecosystems, with high spatial resolution data being extensively utilized in various research studies. However, LAI data under future scenarios are typically only available at 1° or coarser spatial resolutions. In this study, we generated a dataset of 0.05° LAI (F0.05D-LAI) from 1983-2100 in a high spatial resolution using the LAI Downscaling Network (LAIDN) model driven by inputs including air temperature, relative humidity, precipitation, and topography data. The dataset spans the historical period (1983-2014) and future scenarios (2015-2100, including SSP-126, SSP-245, SSP-370, and SSP-585) with a monthly interval. It achieves high accuracy (R² = 0.887, RMSE = 0.340) and captures fine spatial details across various climate zones and terrain types, indicating a slightly greening trend under future scenarios. F0.05D-LAI is the first high-resolution LAI dataset and reveals the potential vegetation variation under future scenarios in China, which benefits vegetation studies and model development in earth and environmental sciences across present and future periods.
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http://dx.doi.org/10.1038/s41597-024-03948-z | DOI Listing |
Cardiovasc Revasc Med
August 2025
Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA. Electronic address:
Secondary mitral regurgitation (SMR) remains a prevalent and challenging complication in patients with heart failure (HF), associated with poor prognosis despite optimal guideline-directed medical therapy (GDMT) and cardiac resynchronization therapy. Current American and European guidelines recommend GDMT as first-line therapy, with transcatheter edge-to-edge repair (TEER) reserved for severe symptomatic SMR patients who remain refractory. However, both guidelines preceded the reporting of pivotal randomized controlled trials (RESHAPE-HF2, MATTERHORN, and EFFORT) and emerging evidence in new clinical scenarios.
View Article and Find Full Text PDFPract Radiat Oncol
September 2025
Department of Radiation Oncology, Institut Bergonié, Bordeaux, France; Centre de Radiothérapie Charlebourg, La Défense, Groupe Amethyst, 65, avenue Foch, 92250 La Garenne-Colombes, France.
Purpose: Urinary toxicity following radical prostatectomy (RP) and postoperative radiotherapy (RT) includes urinary incontinence and vesicourethral anastomosis (VUA) strictures. With the increasing use of stereotactic body radiotherapy (SBRT), dose-escalation, and reirradiation within the prostate bed (PB), standardization of the definition of urinary organs at risk (OARs) in the post-RP setting is needed. This works aims to provide a comprehensive review of the anatomical and physiopathological changes occurring after RP, as well as to provide a consensus on urinary OARs delineation for prostate cancer (PCa) EBRT in the post-RP setting.
View Article and Find Full Text PDFJ Environ Manage
September 2025
Ecological Modelling Laboratory, Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario, M1C 1A4, Canada. Electronic address:
Agriculture intensification represents an essential strategy to ensure food security for the growing human population, but it also poses considerable environmental concerns. Climate change and associated projections of an increased frequency of extreme precipitation and runoff events may amplify nutrient dynamics along the watershed-lake continuum, and could further exacerbate the poor water quality conditions downstream. Identifying hotspot locations with higher propensity for sediment and nutrient export and designing effective mitigation measures at the source is more critical than ever.
View Article and Find Full Text PDFESMO Open
September 2025
Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Bruxelles, Belgium. Electronic address:
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i), such as abemaciclib and ribociclib, have recently been incorporated as adjuvant strategy in combination with endocrine therapy (ET) for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer at higher risk of recurrence. However, despite a significant reduction in recurrence rates, a subset of patients still experiences distant metastatic spreading, with nearly 10% recurring during or shortly after adjuvant CDK4/6i completion, as observed in pivotal trials. To date, only one small retrospective study has described this emerging population while ongoing trials are not specifically addressing this scenario, leaving both the efficacy of postrelapse treatments and the biological background largely unknown.
View Article and Find Full Text PDFNat Biomed Eng
September 2025
State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing, China.
Vision foundation models have demonstrated vast potential in achieving generalist medical segmentation capability, providing a versatile, task-agnostic solution through a single model. However, current generalist models involve simple pre-training on various medical data containing irrelevant information, often resulting in the negative transfer phenomenon and degenerated performance. Furthermore, the practical applicability of foundation models across diverse open-world scenarios, especially in out-of-distribution (OOD) settings, has not been extensively evaluated.
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