Characterization of biogeochemical cycles in agricultural watersheds: Integrating regional modelling assessment with downstream water quality.

Agriculture intensification represents an essential strategy to ensure food security for the growing human population, but it also poses considerable environmental concerns. Climate change and associated projections of an increased frequency of extreme precipitation and runoff events may amplify nutrient dynamics along the watershed-lake continuum, and could further exacerbate the poor water quality conditions downstream. Identifying hotspot locations with higher propensity for sediment and nutrient export and designing effective mitigation measures at the source is more critical than ever.

Comparative outcomes of ERAS and conventional methods in laparoscopic sleeve gastrectomy: a 5-Year prospective cohort study in Saudi Arabia.

Background: The burden of obesity in Saudi Arabia is partly addressed with Laparoscopic Sleeve Gastrectomy (LSG), a bariatric surgical option, but perioperative complications and prolonged hospital stays persist. Enhanced Recovery After Surgery (ERAS) aims to improve postoperative outcomes.

Objectives: To compare the peri-operative LSG outcomes among patients receiving ERAS and conventional bariatric procedures (non-ERAS).

Upregulation of lncRNA ANRASSF1 is associated with the lymph node metastasis and infection in gastric cancer.

Background: Gastric cancer is the fifth most common malignancy worldwide. Early diagnosis of GC can increase survival rate and treatment outcome. In the present study, the expression of lncRNA ANRASSF1 was evaluated in gastric tumor tissues.

A high-gain gap waveguide-based 16 × 16 slot antenna array with low sidelobe level for mmwave applications.

This study presents the design of a high-gain 16 × 16-slot antenna array with a low sidelobe level (SLL) using a tapered ridge gap waveguide feeding network for Ka-band applications. The proposed antenna element includes four cavity-backed slot antennas. A tapered feeding network is designed and utilized for unequal feeding of the radiating elements.

Enhanced predictive modeling of dissolved oxygen concentrations in riverine systems using novel hybrid temporal pattern attention deep neural networks.

Monitoring water quality and river ecosystems is vital for maintaining public health and environmental sustainability. Over the past decade, data-driven methods have been extensively used for river water quality modeling, including dissolved oxygen (DO) concentrations. Despite advancements, challenges persist regarding accuracy, scalability, and adaptability of data-driven models to diverse environmental conditions.

NEAT1 and CHROMR lncRNAs: a promising diagnostic tool for diffuse large B-cell lymphoma especially in elderly patients.

Long non-coding (lnc) RNAs have crucial regulatory roles in molecular pathways, and their dysregulation is associated with the pathogenesis of malignancies such as Diffuse large B-cell lymphoma (DLBCL). Therefore, we aimed to study the NEAT1 and CHROMR expression in DLBCL and explore their association with clinicopathological characteristics. DLBCL and non-tumor lymph node specimens were obtained to assess the expression levels.

Apoptotic effect of melatonin on ER-positive breast cancer cell lines: ADGRL4 gene expression and promoter methylation.

Breast cancer (BC) is the second most common malignancy worldwide. ADGRL4, as a modulator of angiogenesis, undergoes various epigenetic modifications affecting its biological functions. In this study, we aimed to assess ADGRL4 promoter methylation status and its expression levels in primary breast tumors and to evaluate its potency as a plausible prognostic biomarker in BC.

Integrating impacts of climate change on aquatic environments in inter-basin water regulation: Establishing a critical threshold for best management practices.

Inter-basin water diversion (IBWD) is a viable strategy to tackle water scarcity and quality degradation due to climate change and increasing water demand in headwaters regions. Nevertheless, the capacity of IBWD to mitigate the impacts of climate change on water quality has rarely been quantified, and the underlying processes are not well understood. Therefore, this study aims to elucidate how the IBWD manipulated total phosphorus (TP) loading dilution and conveying patterns under climate change and determine a critical threshold for the quantity of water entering downstream reservoirs (W) for operational scheduling.

Melatonin administration during the first half of pregnancy improves the reproductive performance of rabbits: Emphasis on ovarian and placental functions.

This study was designed to investigate the roles of melatonin administration during different sensitive windows of the first half of pregnancy in the function and gene expression of the ovary and placenta, hormone profile, and pregnancy outcomes in rabbits. Four equal experimental groups of 20 rabbits each were used. The first (FW), second (SW), and third (F + SW) groups comprised rabbits that orally received 0.

Development and validation of a nomogram model for lung cancer based on radiomics artificial intelligence score and clinical blood test data.

Background: Artificial intelligence AI) discrimination models using single radioactive variables in recognition algorithms of lung nodules cannot predict lung cancer accurately. Hence, we developed a clinical model that combines AI with blood test variables to predict lung cancer.

Methods: Between 2018 and 2021, 584 individuals (358 patients with lung cancer and 226 individuals with lung nodules other than cancer as control) were enrolled prospectively.

Teaching Medical Professionalism with a Scenario-based Approach Using Role-Playing and Reflection: A Step towards Promoting Integration of Theory and Practice.

Introduction: Professionalism, as one of the core competencies of physicians, is essential for providing the patients with higher quality care. It is an abstract concept and its education and assessment need objective and operational methods. The present study aimed at teaching the concepts of professionalism based on a scenario-based approach using role-playing and reflection.

Ectopic expression of lncRNA MVIH as a potential diagnostic biomarker in cervical cancer.

Aim: Cervical cancer (CC) is one of the most common cancers in women. Recent advances in screening and vaccination against the papilloma virus (HPV) have increased protection against CC. However, there is no effective diagnostic biomarker and treatment approach during the course of the disease.

Expression of lncRNAs AK058003 and APOC1P1 in breast cancer patients.

In the current study, the expression levels of two important lncRNAs, i.e., AK058003 and APOC1P1, in breast tumors were compared with adjacent non-tumor tissues to evaluate their diagnostic potential in a panel of 121 patients.

Prognostic Value of LncRNA KRT18P55 in Patients with Intestinal Type of Gastric Cancer.

Purpose: Gastric cancer (GC) is a heterogeneous disease, and this heterogeneity significantly affects survival and treatment outcomes. Identification of molecular biomarkers specific for early-stage GC can help clinicians to choose more precise and effective treatment approaches. Long non-coding RNAs (lncRNAs) have the potential to be used as biomarkers because of their tissue specificity, stability, and availability in body fluids.

(doum)-derived extract alleviates hyperglycemia in diabetic rats: a comprehensive , and study.

In the present study, we investigated the hypoglycemic effect of different extracts ( organic and aqueous) derived from the fruits of (doum) on male streptozotocin-induced diabetic rats. Blood glucose levels as well as the relative gene expression of insulin, TNF-α, and TGF-β were determined in the pancreatic tissue of the experimental animals. Treatment of STZ-induced diabetic rats with aqueous extracts of the plant fruit over 7 weeks significantly reduced the elevated blood glucose and increased the relative expression of insulin, while the relative expression of inflammatory mediators ( TNF-α and TGF-β) was significantly reduced.

Cancer driver gene and non-coding RNA alterations as biomarkers of brain metastasis in lung cancer: A review of the literature.

Brain metastasis (BM) is the most common event in patients with lung cancer. Despite multimodal treatments and advances in systemic therapies, development of BM remains one of the main factors associated with poor prognosis and mortality in patients with lung cancer. Therefore, better understanding of mechanisms involved in lung cancer brain metastasis (LCBM) is of great importance to suppress cancer cells and to improve the overall survival of patients.

Moderate Prognostic Value of lncRNA FOXD2-AS1 in Gastric Cancer with Helicobacter pylori Infection.

Purpose: Gastric cancer (GC) is one of the most frequent tumors worldwide and identification of a sensitive and specific prognostic biomarker is of great importance. Long non-coding RNAs (lncRNAs) play crucial roles in tumorigenesis of various malignancies. In the present study, we investigated lncRNA FOXD2-AS1 expression in gastric tumors and assessed its potential as a prognostic biomarker.

Effects of heavy metal contamination released by petrochemical plants on marine life and water quality of coastal areas.

The present study attempts to assess the threat of water contamination in Persian Gulf by heavy metals (Fe, Cr, Pb, Cu, Zn, Cd, Se, and Ni) and its subsequent effects on five fish species including Scomberomorus guttatus (S. guttatus), Lethrinus nebulosus (L. nebulosus), Brachirus orientalis (B.

Key Epigenetic Events Involved in the Maintenance of Breast Cancer Stem Cells.

Background: Cancer stem cells (CSCs) are a small subpopulation of cells within tumors and play significant roles in tumorigenesis, metastasis, resistance to treatment, and relapse. They are defined by self-renewal and multi-lineage differentiation, and aggressiveness. Epigenetic modifications, including DNA methylation and acetylation, histone modifications, and non-coding.

An All-In-One Transcriptome-Based Assay to Identify Therapy-Guiding Genomic Aberrations in Nonsmall Cell Lung Cancer Patients.

The number of genomic aberrations known to be relevant in making therapeutic decisions for non-small cell lung cancer patients has increased in the past decade. Multiple molecular tests are required to reliably establish the presence of these aberrations, which is challenging because available tissue specimens are generally small. To optimize diagnostic testing, we developed a transcriptome-based next-generation sequencing (NGS) assay based on single primed enrichment technology.

Anti-Cancer Effect of Melatonin via Downregulation of Delta-like Ligand 4 in Estrogen-Responsive Breast Cancer Cells.

Background: The Notch signaling pathway has a key role in angiogenesis and Delta - Like Ligand 4 (DLL4) is one of the main ligands of Notch involved in cell proliferation in sprouting vessels.

Objective: In this study, we aimed to evaluate the expression of DLL4 in primary breast tumors and to examine the effect of melatonin on DLL4 expression in vitro.

Methods: Eighty-five breast tumor and paired adjacent non-tumor tissue samples were collected.

Transcriptional activation of cyclin D1 via HER2/HER3 contributes to EGFR-TKI resistance in lung cancer.

Several different mechanisms are implicated in the resistance of lung cancer cells to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), and only few have been functionally investigated. Here, using genetically knocked out EGFR and TKI-resistant lung cancer cells, we show that loss of wild-type EGFR attenuates cell proliferation, migration and 3D-spheroid formation, whereas loss of mutant EGFR or resistance to TKIs reinforces those processes. Consistently, disruption of wild-type EGFR leads to suppression of HER2/HER3, while mutant EGFR ablation or resistance to TKIs increases HER2/HER3 expression, compensating for EGFR loss.

A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer.

Chronic venous ulcer (CVU) is a major cause of chronic wounds of lower extremities and presents a significant financial and resource burden to health care systems worldwide. Defects in the vasculature, matrix deposition, and re-epithelialization are the main histopathological changes believed to impede healing. Supplementation of the amino acid arginine that plays a crucial role in the interactions that occur during inflammation and wound healing was proven clinically to improve acute wound healing probably through enhancing activity of inducible arginase (AI) locally in the wounds.