Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Automated batch and flow setups are well-established for high throughput experimentation in both thermal chemistry and photochemistry. However, the development of automated electrochemical platforms is hindered by cell miniaturization challenges in batch and difficulties in designing effective single-pass flow systems. In order to address these issues, we have designed and implemented a new, slug-based automated electrochemical flow platform. This platform was successfully demonstrated for electrochemical C-N cross-couplings of E3 ligase binders with diverse amines (44 examples), which were subsequently transferred to a continuous-flow mode for confirmation and isolation, showing its applicability for medicinal chemistry purposes. To further validate the versatility of the platform, Design of Experiments (DoE) optimization was performed for an unsuccessful library target. This optimization process, fully automated by the platform, resulted in a remarkable 6-fold increase in reaction yield.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627123 | PMC |
| http://dx.doi.org/10.1002/anie.202412045 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Next-Generation Miniaturized Separation Platforms: Converging Detection, Automation, and Sustainable Design for Intelligent Analytical Science.
Crit Rev Anal Chem
September 2025
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysore, India.
The miniaturization of separation platforms marks a transformative shift in analytical science, merging microfabrication, automation, and intelligent data integration to meet rising demands for portability, sustainability, and precision. This review critically synthesizes recent technological advances reshaping the field-from microinjection and preconcentration modules to compact, high-sensitivity detection systems including ultraviolet-visible (UV/Vis), fluorescence (FL), electrochemical detection (ECD), and mass spectrometry (MS). The integration of microcontrollers, AI-enhanced calibration routines, and IoT-enabled feedback loops has led to the rise of self-regulating analytical devices capable of real-time decision-making and autonomous operation.
View Article and Find Full Text PDFElectronically controlled deprotection chemistry for multiplex enzymatic DNA synthesis on a chip with single-base resolution.
Lab Chip
September 2025
State Key Laboratory of Radio Frequency Heterogeneous Integration, Shanghai Jiao Tong University, Shanghai 200240, China.
Enzymatic deoxyribonucleic acid (DNA) synthesis (EDS) is an environmentally friendly approach capable of generating longer and more complex sequences than chemical synthesis, making it a promising next-generation technology for high-throughput single-stranded DNA production. However, precise sequence control at high throughput remains a key challenge. Here, we present a novel electronically controlled deprotection chemistry (ECDC) integrated with a hydrogel-primer modification system on-chip for efficient multiplexed EDS.
View Article and Find Full Text PDFFast and accurate diagnosis of G6PD deficiency via NADPH monitoring using sequential injection analysis coupled with electrochemical detection.
Talanta
August 2025
Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand. Electronic address:
A rapid and automated determination of nicotinamide adenine dinucleotide phosphate (NADPH) is proposed and applied to the evaluation of glucose-6-phosphate dehydrogenase (G6PD) deficiency in real samples. To this end, a sequential injection analyzer with electrochemical detection (SIA-ECD) is proposed with 0.1 mol L Tris-HCl (pH 8.
View Article and Find Full Text PDFBeyond drive cycles: mapping the intricacies of electric vehicle battery health in diverse environments and driving conditions.
RSC Adv
August 2025
Department of Electronics and Electrical Engineering, Indian Institute of Technology Guwahati Assam 781039 India
As electric two-wheelers become increasingly prevalent in emerging markets, understanding the real-world degradation of their batteries is crucial for ensuring reliability, longevity, and cost-effectiveness. Traditional battery aging studies are heavily based on standard drive cycles that do not capture the variability introduced by diverse user behaviors, regional conditions, and charging habits. This study proposes a comprehensive and adaptable framework for evaluating the end-of-life (EOL) of EV batteries in realistic usage scenarios.
View Article and Find Full Text PDFOne-step electrochemical conversion of propane to acetone of 96% purity.
Nat Commun
August 2025
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
Acetone is a crucial chemical and solvent with extensive industrial applications, traditionally synthesized from propane through multi-step processes that demand high temperatures and pressures. Here, we report a selective one-step conversion of propane to acetone using a heterogeneous electro-Fenton process (h-EFP) under mild conditions. In this process, concentrated ·OH radicals are generated in an iron/carbon hybrid cathode via a two-electron oxygen reduction reaction followed by HO conversion.
View Article and Find Full Text PDF