98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949445 | PMC |
http://dx.doi.org/10.4103/aja202451 | DOI Listing |
FEBS Open Bio
September 2025
Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, China.
Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs. Xenotransplantation of chicken PGCs can achieve germline transmission. However, there are still challenges in obtaining many PGCs from endangered birds in vitro.
View Article and Find Full Text PDFReproduction
October 2025
State Key Laboratory of Reproductive Medicine and Offspring Health, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
In Brief: Lipid homeostasis is vital for maintaining testicular function and male fertility, but the specific contributions of lipid-regulating enzymes remain unclear. This study shows that DGKη, although highly expressed in the testis, is not essential for spermatogenesis but modulates testicular lipid metabolism in response to dietary conditions.
Abstract: Diacylglycerol kinase eta (DGKη), encoded by the Dgkh gene, catalyzes the phosphorylation of diacylglycerol to phosphatidic acid, both of which are key lipid second messengers.
Front Cell Dev Biol
August 2025
Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, China.
Background: Methotrexate (MTX), a folate antagonist, is widely used in the treatment of tumors and autoimmune diseases such as rheumatoid arthritis (RA), due to its antiproliferative, antimetabolic, and potent anti-inflammatory properties. However, high-dose or long-term use of MTX can result in toxicity to the gastrointestinal, hemopoietic, and reproductive tissues. Yunpi Jiedu Tongluo Qushi Decoction (YJT), an effective Chinese herbal formula, is utilized in RA treatment to mitigate the toxic and side effect of MTX.
View Article and Find Full Text PDFMater Today Bio
October 2025
Department of Reproductive Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Clinically, even in patients diagnosed with non-obstructive azoospermia, spermatogenesis may be present in some seminiferous tubules, which gives the patient hope of having biological offspring of his own. However, there is still a blank for high-precision detection technologies to support accurate diagnosis and effective treatment. In this work, we successfully developed a minimally invasive fine needle detection memristive device that features a structure composed of Ag/CH-MnO/FTO by utilizes the organic-inorganic heterojunction as functional layer.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, The Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
Background: Obesity is associated with hormonal imbalance, increased oxidative stress, and inflammation in the testis. These conditions adversely affect sperm quality, leading to impaired male fertility. Therefore, therapeutic interventions to counteract the adverse effects of obesity are crucial.
View Article and Find Full Text PDF