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Article Abstract
is a serious citrus pest. Dinotefuran is highly insecticidal against . To analyze the sublethal effects of dinotefuran on adults, an indoor toxicity test was performed, which revealed that the lethal concentration 50 (LC) values were 4.23 and 0.50 μg/mL for 24 and 48 h treatments, respectively. RNA-Seq led to the identification of 71 and 231 differentially expressed genes (DEGs) after dinotefuran treatments with LC and LC doses, respectively. Many of the DEGs are significantly enriched in the apoptosis pathway. Dinotefuran-induced apoptosis in the gut cells was confirmed through independent assays of 4',6-diamidino-2-phenylindole (DAPI) and TdT-mediated dUTP nick end labeling (TUNEL) staining. Increased levels of reactive oxygen species (ROS) and a loss of mitochondrial membrane potential were observed. Four caspase genes were identified, and dinotefuran treatments resulted in increased mRNA levels of and . These findings shed light on the sublethal effects of dinotefuran on .
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| http://dx.doi.org/10.1021/acs.jafc.4c06081 | DOI Listing |
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