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A family of peptides known as bioactive peptides has unique physiological properties and may be used to improve human health and prevent illness. Because bioactive peptides impact the immunological, endocrine, neurological, and cardiovascular systems, they have drawn a lot of interest from researchers. According to recent studies, bioactive peptides have a lot to offer in the treatment of inflammation, neuronal regeneration, localized ischemia, and the blood-brain barrier. It investigates various peptide moieties, including antioxidative properties, immune response modulation, and increased blood-brain barrier permeability. It also looks at how well they work as therapeutic candidates and finds promising peptide-based strategies for better outcomes. Furthermore, it underscores the need for further studies to support their clinical utility and suggests that results from such investigations will enhance our understanding of the pathophysiology of these conditions. In order to understand recent advances in BPs and to plan future research, academic researchers and industrial partners will find this review article to be a helpful resource.
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http://dx.doi.org/10.2174/0118715273316382240807120241 | DOI Listing |
Arch Toxicol
September 2025
Laboratorio de Proteómica, Facultad de Microbiología, Instituto Clodomiro Picado, Universidad de Costa Rica, San José, 11501, Costa Rica.
The scorpion Hottentotta judaicus inhabits the Levant region of the Middle East, including Lebanon, Jordan, Palestine, and Israel. While previous research focused on its insecticidal properties and sodium-channel-targeting toxins, its venom remains largely unexplored using modern proteomic approaches. We analyzed the venom composition of H.
View Article and Find Full Text PDFBioconjug Chem
September 2025
Pôle Chimie Balard, IBMM - UMR 5247, 1919, Route de Mende, 34293 Montpellier cedex 5, France.
Phosphole-based fluorophores are attractive dyes for bioimaging due to their relatively compact molecular structures, strong fluorescence up to the near-infrared region with large Stokes shifts, and remarkable resistance to photobleaching. Therefore, the development of efficient and chemoselective coupling methods for functionalizing phospholes is of significant interest for biomolecular labeling. Herein, we describe the synthesis of novel P-aminophospholes and their use for direct conjugation to cysteinyl peptides under mild conditions.
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Haidian 100080, China.
Metal ions play a vital role in the health of the modern human body, but deficiencies in mineral elements have created health risks worldwide. However, mineral supplements currently available on the market are very limited due to poor solubility, low bioavailability, and the possibility of adverse effects on the gastrointestinal tract. In contrast, protein-derived metal-chelating peptides have received a lot of attention because of their stability, safety, and very high bioavailability.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
Navy Special Medical Centre, Second Military Medical University, Shanghai, China.
Radiation exposure initiates a cascade of reactions, including the release of reactive oxygen species, DNA double-strand breaks, and cellular apoptosis, leading to cell death, tissue damage, and potentially the development of cancer. Consequently, there is an urgent need to develop highly effective and low-toxicity radioprotective agents. Traditional chemically synthesized protective agents face significant limitations in clinical applicability due to their pronounced off-target toxicity, narrow therapeutic window, and high production costs.
View Article and Find Full Text PDFJ Mater Chem B
September 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.
Globally, new antibiotic development lags behind the rapid evolution of antibiotic-resistant bacteria. Given the extensive research and development cycles, high costs, and risks associated with new pharmaceuticals, exploring alternatives to conventional antibiotics and enhancing their efficacy and safety is a promising strategy for addressing challenges in the post-antibiotic era. Previous studies have shown that antimicrobial peptides/peptidomimetics (AMPs) primarily use a membrane-disruption mechanism distinct from conventional antibiotics to exert bactericidal effects.
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