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Article Abstract
The increasing resistance of agricultural pests to existing acaricides presents a significant challenge to sustainable agriculture. Therefore, this study introduced , a novel isoindolinone-based phenyl trifluoroethyl thioether derivative generated through an innovative design strategy combining bioisosterism and novel cyclization methods. We synthesized several compounds and evaluated their acaricidal efficacy against in greenhouses and in field settings. emerged as a standout candidate, demonstrating a lower median lethal concentration (LC) of 0.722 mg/L compared to the commercial acaricide, cyetpyrafen. Notably, 30 days after application, showed a field control efficacy of 96.4% against , highlighting its potential for broader applications. The results underscore the utility of the isoindolinone scaffold in pesticide development, offering a promising solution to combat pest resistance with implications for enhanced crop protection and agricultural productivity. Future studies should explore the detailed mode of action of and its potential applicability across diverse agricultural settings, further confirming its role as a sustainable solution for pest management.
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