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http://dx.doi.org/10.1186/s13244-024-01773-x | DOI Listing |
Anal Chim Acta
November 2025
School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, PR China. Electronic address:
Even small deviations in modulation timing (DMT) can cause discrepancies between the originally set modulation period (P) and the actual P in comprehensive two-dimensional gas chromatography (GC × GC) analysis. This study explored the impact of DMT on the accuracy of the second dimensional retention time (t) and the second dimensional retention index (I) calculations and introduced a line detection technology (LDT) based on the Hough Transform to correct DMT-induced t shifts. The correction was achieved by automatically adjusting candidate P values until the slope of the line(s) (CB_line(s)) formed by column bleeding compound peaks in the isothermal section of the contour plot approached zero, thereby determining the actual P.
View Article and Find Full Text PDFJ Physiol
September 2025
Department of Physiology, Anatomy & Genetics, University of Oxford and Daegu-Gyeongbuk Institute of Science and Technology, South Korea.
The cardiac pacemaker activity is formed from multiple interlocking physiological networks, any one of which can generate rhythm. The interlocking is reciprocal so that they automatically replace each other. In such interlocking control systems, the association scores for individual components are necessarily low, even though causation, measured by the electric current carried by the relevant ion channels, is large.
View Article and Find Full Text PDFNature
September 2025
Department of Orthopaedics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
We introduce Generative, Adaptive, Context-Aware 3D Printing (GRACE), a new approach combining 3D imaging, computer vision and parametric modelling to create tailored, context-aware geometries using volumetric additive manufacturing. GRACE rapidly and automatically generates complex structures capable of conforming directly around features ranging from cellular to macroscopic scales with minimal user intervention. Here we demonstrate its versatility in applications ranging from synthetic objects to biofabrication, including adaptive vascular-like geometries around cell-laden bioinks, resulting in improved functionality.
View Article and Find Full Text PDFSci Rep
September 2025
Mechatronics Engineering Department, Engineering Faculty, Erciyes University, Kayseri, Turkey.
Anal Chem
September 2025
Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid 28029, Spain.
Oxidative damage plays a critical role in various diseases including cardiovascular and neurological disorders. Thiol redox reactions, acting as oxidative stress sensors, influence protein structure and function. Redox proteomics, based on the differential alkylation of cysteine sites followed by mass spectrometry, enables the comprehensive analysis of thiol redox status in cells and tissues.
View Article and Find Full Text PDF