Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Bone defect disease seriously endangers human health and affects beauty and function. In the past five years, the three dimension (3D) printed radially graded triply periodic minimal surface (TPMS) porous scaffold has become a new solution for repairing bone defects. This review discusses 3D printing technologies and applications for TPMS scaffolds. To this end, the microstructural effects of 3D printed TPMS scaffolds on bone regeneration were reviewed and the structural characteristics of TPMS, which can promote bone regeneration, were introduced. Finally, the challenges and prospects of using TPMS scaffolds to treat bone defects were presented. This review is expected to stimulate the interest of bone tissue engineers in radially graded TPMS scaffolds and provide a reliable solution for the clinical treatment of personalised bone defects.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283664PMC
http://dx.doi.org/10.1177/20417314241263689DOI Listing

Publication Analysis

Top Keywords

tpms scaffolds
20
bone regeneration
12
bone defects
12
printed tpms
8
bone
8
radially graded
8
tpms
7
scaffolds
5
novel printed
4
scaffolds microstructure
4

Similar Publications

Triply periodic minimal surface (TPMS) scaffolds are gaining attention in tissue engineering due to their continuous and interconnected porous architecture. In this study, three TPMS geometries-Gyroid, Diamond, and I-WP-were fabricated from polylactic acid (PLA) using fused deposition modeling (FDM), with all scaffolds designed to maintain the same overall porosity. Scaffold characterization included scanning electron microscopy (SEM), microcomputed tomography (micro-CT), compressive mechanical testing, and surface wettability analysis.

View Article and Find Full Text PDF

Design and in vitro evaluation of gradient Schwarz Primitive scaffolds with thin-board integration for bone implants.

Biomater Adv

December 2025

College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310023, People's Republic of China; Key Laboratory of Special Purpose Equipment and Advanced Processing Technology, Ministry of Education, Zhejiang University of Technology, Hangzhou 310023, People's Republic of China; Zh

Bone scaffolds for the repair of large-segment bone defects require a balance between mechanical stability and nutrient transport. This study proposes gradient Schwarz Primitive minimal surface scaffolds (P-TPMS) integrated with thin-board (B) structures, fabricated via selective laser melting (SLM). Finite element analysis (FEA) revealed that the gradient design reduced stress concentrations, achieving a layer-by-layer collapse failure mode under compression.

View Article and Find Full Text PDF

Scaffolds developed from Triply Periodic Minimal Surface (TPMS) structures effectively mimic the geometric, mechanical, and fluid transport characteristics of human bones. These porous architectures facilitate fluid flow and augment bone cell adhesion and proliferation through their substantial surface area. In this study, the potential of network solid and sheet solid TPMS scaffolds with the same Schwarz Primitive architecture was compared for bone regeneration.

View Article and Find Full Text PDF

Ceramic stereolithography scaffolds with designs based on triple periodic minimal surfaces (TPMS) were developed for potential applications in bone tissue regeneration. An acrylic-based resin with calcium phosphate nanoparticles were used. Particles were synthesized via Combustion in solution, resulting in hydroxyapatite and β-TCP phases.

View Article and Find Full Text PDF

3D-printed TPMS-structured hybrid PLA/MgTiO scaffolds: Synergizing bioactivity and antibacterial performance for bone regeneration.

Biomater Adv

December 2025

Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati, India; Department of Mechanical Engineering, Indian Institute of Technology Palakkad, Palakkad, India. Electronic address:

Bone repair and tissue engineering require biomaterials that offer both mechanical stability and biocompatibility. Titanium is renowned for its mechanical durability but has limited bioactivity, whereas magnesium offers high bioactivity but degrades too quickly. This study develops a novel hybrid scaffold using fused filament fabrication (FFF) to combine polylactic acid (PLA) with magnesium titanate (MgTiO).

View Article and Find Full Text PDF