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http://dx.doi.org/10.1002/ctm2.1629 | DOI Listing |
Biosci Trends
August 2025
Department of Neurosurgery, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, China.
Early-stage diagnosis offers the greatest survival advantage in oncology, and yet conventional liquid-biopsy markers - circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) - depend on cell death or mechanical shedding and therefore appear late in disease progression. Exosomes, 40-160 nm lipid-bilayer vesicles secreted by viable cells, emerge earlier, outnumber CTCs by several orders of magnitude, and preserve multi-omic cargo that mirrors intratumor heterogeneity. Rapid advances in enabling technologies are driving continual breakthroughs in exosome-based liquid biopsy, laying a solid foundation for its accelerated translation into clinical practice.
View Article and Find Full Text PDFUrol Oncol
July 2025
Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh. Electronic address:
Cancer continues to pose a significant global health challenge, driving the need for innovative approaches in early detection and treatment management. Exosomes, small extracellular vesicles secreted by various cell types, play a pivotal role in intercellular communication by transferring molecular cargo between donor and recipient cells. They have emerged as key players in cancer progression and therapy.
View Article and Find Full Text PDFJAMA Surg
September 2025
Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, Monrovia, California.
Importance: Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide, primarily attributed to delayed detection. The invasive and cost-prohibitive nature of endoscopy for GC screening highlights the urgent need for noninvasive biomarkers.
Objective: To develop an exosome-based diagnostic signature to facilitate blood-based, early detection of patients with GC.
Adv Healthc Mater
July 2025
Department of Bioengineering and Nano-Bioengineering, Research Center for Bio Materials and Process Development, Incheon National University, Incheon, 22012, Republic of Korea.
Membrane fusion, a foundational process in biological systems, has inspired the development of nanomaterials with transformative potential in biomedical applications, particularly in the diagnosis of infectious diseases and cancer. By emulating nature's intricate fusion mechanisms, these biomimetic nanomaterials offer unparalleled sensitivity, specificity, and versatility for detecting disease-related biomarkers. Recent advancements have focused on engineering lipid nanoparticles that mimic viruses or exosomes, incorporating functionalization and signal amplification systems to enable targeted biomarker recognition and precise molecular interactions.
View Article and Find Full Text PDFMed Oncol
July 2025
Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia.
Exosomal non-coding RNAs (ncRNAs) play a key role in regulating apoptosis in lung cancer, influencing tumor progression and therapeutic resistance. This review examines how exosomal ncRNAs, including miRNAs, lncRNAs, and circRNAs, modulate apoptotic pathways in the tumor microenvironment. This review examines how exosomal ncRNAs, composed of three types, including miRNAs, lncRNAs, and circRNAs, control apoptotic pathways in the tumor microenvironment.
View Article and Find Full Text PDF