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Article Abstract
Tissue-resident memory T cells (T) can be induced by infection and vaccination, and play a key role in maintaining long-term protective immunity against mucosal pathogens. Our studies explored the key factors and mechanisms affecting the differentiation, maturation, and stable residence of gastric epithelial CD4 T induced by Helicobacter pylori (Hp) vaccine and optimized Hp vaccination to promote the generation and residence of T. Cluster of differentiation (CD)38 regulated mitochondrial activity and enhanced transforming growth factor-β signal transduction to promote the differentiation and residence of gastric epithelial CD4 T by mediating the expression of CD105. Extracellular nucleotides influenced the long-term maintenance of T in gastric epithelium by the P2X7 receptor (P2RX7). Vitamin D3 and Gram-positive enhancer matrix (GEM) particles as immune adjuvants combined with Hp vaccination promoted the production of CD69CD103CD4 T.
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| http://dx.doi.org/10.1016/j.mucimm.2024.06.011 | DOI Listing |
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