98%
921
2 minutes
20
Objectives: In this article, we estimate the initial and temporal impacts of generic entry on benchmark drug prices as reimbursed through the Pharmaceutical Benefits Scheme of Australia and the degree to which further generic competition affects these prices under the current regulatory framework.
Methods: We construct a panel data set consisting of 781 Pharmaceutical Benefits Scheme listed drugs over a 95-month time period and use fixed-effect regressions. The dynamic price effects of generic competition are investigated by implementing panel methods.
Results: Our results suggest that generic entry into the Australian pharmaceutical market causes significant initial price reductions of approximately 31% and that successive generic entrants also act to further reduce drug prices. Through subgroup analyses, we identify that the effect of generic competition varies significantly according to the drug's therapeutic group and mode of drug administration and the dynamic analysis indicates that generic entry results in continuous price reductions even after large initial drops.
Conclusions: Generic competition reduces reimbursed drug prices in Australia to a greater extent than previous research has identified, although the average price effects can vary significantly depending on a drug's therapeutic group or mode of drug administration. Prices generally continue to fall significantly over time under the price disclosure mechanism.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.vhri.2024.101008 | DOI Listing |
Front Neurol
August 2025
Department of Neurology, Gulhane Medical Faculty, University of Health Sciences, Ankara, Türkiye.
Introduction: Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder of the neuromuscular junction, with limited large-scale epidemiological data. In this study, we aimed to determine the epidemiological profile of LEMS in Türkiye, and to assess associated malignancies, mortality, and prescription rates of pyridostigmine and amifampridine.
Methods: We identified LEMS cases through a retrospective review of clinical records for individuals with a G73.
Appl Biosaf
August 2025
MRIGlobal, Gaithersburg, Maryland, USA.
Introduction: Body piercings in laboratory environments have received limited attention in biosafety literature despite their increasing prevalence in the workforce. The purpose of this review is to compile and collate the current recommendations, practices, and literature on wearing body piercings in and out of biological laboratories, thereby providing a clearer understanding of the topic, supporting biosafety professionals in developing informed institutional policies, and identifying gaps for future applied biosafety research.
Methods: Online literature reviews were performed, encompassing both domestic (U.
PLoS One
September 2025
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Background: Foreign-born children may face greater barriers to accessing routine immunizations in Canada or their country of birth, but provincial surveillance data on immigration status are lacking. Using our provincial immunization repository linked to administrative data, we assessed immunization coverage among immigrant and refugee children in Ontario, Canada, compared with Ontario-born children and identified factors associated with being up-to-date (UTD).
Methods: We conducted a retrospective cohort study of children entering school during the 2012/13-2014/15 school years.
J Clin Invest
September 2025
Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America.
Background: Statin therapy lowers the risk of major adverse cardiovascular events (MACE) among people with HIV (PWH). Residual risk pathways contributing to excess MACE beyond low-density lipoprotein cholesterol (LDL-C) are not well understood. Our objective was to evaluate the association of statin responsive and other inflammatory and metabolic pathways to MACE in the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE).
View Article and Find Full Text PDFJ Imaging Inform Med
September 2025
Department of Radiology, University of Cincinnati, Cincinnati, OH, USA.
Background: Ocular imaging is essential to the diagnosis and management of eye disease, yet standardized imaging workflows remain underdeveloped in the eye care setting. This manuscript describes the design and implementation of an orders-based imaging workflow for ambulatory ophthalmology integrated with the electronic health record and enterprise imaging systems.
Methods: We developed a DICOM-compliant workflow for pediatric ophthalmology imaging that supports HL7 integration, DICOM modality worklists, and enterprise archive storage.