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, also called bladdernuts, is a genus of plants belonging to the family Staphyleaceae, widespread in tropical or temperate climates of America, Europe, and the Far East. spp. produce bioactive metabolites with antioxidant properties, including polyphenols which have not been completely investigated for their phytotherapeutic potential, even though they have a long history of use for food. Here, we report the isolation of six flavonol glycosides from the hydroalcoholic extract of aerial parts of L., collected in Italy, using a solid-phase extraction technique. They were identified using spectroscopic, spectrometric, and optical methods as three quercetin and three isorhamnetin glycosides. Among the flavonol glycosides isolated, isoquercetin and quercetin malonyl glucoside showed powerful antioxidant, antimicrobial, and wound healing promoting activity and thus are valuable as antiaging ingredients for cosmeceutical applications and for therapeutic applications in skin wound repair.
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http://dx.doi.org/10.3390/ijms25115582 | DOI Listing |
Mol Biol Rep
September 2025
Department of Biotechnology, Daegu University, Gyeongsan, 38453, Republic of Korea.
Background: Bacterial pathogen-associated molecular patterns (PAMPs), specifically lipopolysaccharide (LPS) from Gram-negative bacteria (E. coli, P. aeruginosa) and lipoteichoic acid (LTA) from Gram-positive bacteria (S.
View Article and Find Full Text PDFJ Prev Alzheimers Dis
September 2025
Omphalos Bioscience LLC, Sandia Park NM 87047, USA.
Four studies now document reduced incidence of Alzheimer's disease (AD) or dementia diagnoses in aging individuals who report higher dietary intake of flavonols (or their glycosides) years prior to diagnosis vs those with lower intake. These effects are large, almost 50 %, for individuals at higher genetic risk for AD, providing a robust gene x environment interaction. They display a specific structure-activity relationship.
View Article and Find Full Text PDFPharmaceuticals (Basel)
July 2025
Qinghai Key Laboratory of Qinghai-Tibetan Plateau Biological Resources, Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, CAS, Xining 810008, China.
Reducing postprandial blood glucose (PBG) is a crucial strategy for treating diabetes and minimizing the risk of complications. Developing efficient and safe -glycosidase inhibitors from natural products to lower PBG has attracted much attention. L.
View Article and Find Full Text PDFMedicina (Kaunas)
July 2025
Department of Anatomy, Faculty of Medicine, Dicle University, Diyarbakır 21280, Turkey.
: This study aimed to investigate the anticancer effects and potential synergistic interactions of quercetin (Q) and doxorubicin (Dox) on the MG-63 osteosarcoma (OS) cell line. Specifically, the effects of these agents on cell viability, apoptosis, reactive oxygen species (ROS) generation, antioxidant defense, and the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt1) signaling pathway were evaluated. : MG-63 cells were cultured and treated with varying concentrations of Q and Dox, both individually and in combination (fixed 5:1 molar ratio), for 48 h.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Department of Food Science and Technology, Pusan National University, Miryang 50463, Republic of Korea.
Bee pollen is a primary and secondary metabolite-rich natural product collected by pollinators such as honeybees. Polyphenols, particularly flavonoids, are well known for their potent antioxidant activities. Numerous phytochemical and biological studies have focused on , a member of the Fagaceae family.
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