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Objectives: The objective of this investigation was to assess the stress and displacement pattern of the craniomandibular complex by employing finite element methodology to simulate diverse angulations of inclined planes that are incorporated in the Twin Block appliance.
Methods: A 3D finite element representation was established by use of Cone Beam Computed Tomography (CBCT) scans. This comprehensive structure included craniofacial skeletal components, the articular disc, a posterior disc elastic layer, dental elements, periodontal ligaments, and a Twin Block appliance. This investigation is the first to incorporated inclined planes featuring three distinct angulations (45, 60, and 70°) as the study models. Mechanical impacts were evaluated within the glenoid fossa, tooth, condylar, and articular disc regions.
Results: In all simulations, the stress generated by the Twin Block appliance was distributed across teeth and periodontal ligament, facilitating the anterior movement of mandibular teeth and the posterior displacement of maxillary teeth. Within the temporomandibular joint region, compressive forces on the superior and posterior facets of the condyle diminished, coinciding with the stress configuration that fosters condylar and mandibular growth. Stress dispersion homogenized in the condylar anterior facet and articular disc, with considerable tensile stress in the glenoid fossa's posterior aspect conforming to stress distribution that promote fossa reconfiguration. The 70° inclined plane exerts the highest force on the tissues. The condyle's maximum and minimum principal stresses are 0.36 MPa and -0.15 MPa, respectively, while those of the glenoid fossa are 0.54 MPa and -0.23 MPa.
Conclusion: Three angled appliances serve the purpose of advancing the mandible. A 45° inclined plane relative to the occlusal plane exerts balanced anteroposterior and vertical forces on the mandibular arch. Steeper angles yield greater horizontal forces, which may enhance forward growth and efficient repositioning.
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http://dx.doi.org/10.1016/j.jmbbm.2024.106603 | DOI Listing |
Commun Med (Lond)
August 2025
School of Medical Technology, Beijing Institute of Technology, Beijing, China.
Background: In percutaneous coronary intervention (PCI), the ability to predict post-PCI fractional flow reserve (FFR) and stented vessel informs procedural planning. However, highly precise and effective methods to quantitatively simulate coronary intervention are lacking. This study developed and validated a virtual coronary intervention (VCI) technique for non-invasive physiological and anatomical assessment of PCI.
View Article and Find Full Text PDFShanghai Kou Qiang Yi Xue
June 2025
Hefei Stomatology Hospital and Anhui Medical University Hefei School of Stomatology. Hefei 230001, China. E-mail:
Purpose: To evaluate the clinical effect of a new fixed Twin-block on adolescent patients with skeletal ClassⅡ malocclusion.
Methods: Twenty-one patients aged 10-13 years with skeletal ClassⅡ malocclusion with mandibular retrusion were chosen for functional treatment using a new fixed Twin-block. Before and after treatment, panoramic and cephalometric films were taken, and the observation indexes were measured and recorded.
J Conserv Dent Endod
August 2025
Department of Conservative Dentistry and Endodontics, Al-Badar Rural Dental College and Hospital, Kalaburagi, Karnataka, India.
Background: All-in-one irrigants introduced recently claim to impart added benefits for endodontic disinfection; however, their effects on root dentin need to be evaluated.
Aims: The aim of the study was to evaluate the dentinal wettability and surface roughness of Triton and Twin Kleen irrigating solutions on root dentin.
Materials And Methods: Eighty dentin blocks (6 mm × 6 mm) were prepared using middle root portion obtained by horizontal sectioning of forty single-rooted extracted human mandibular premolar teeth which were further mounted in acrylic blocks (4 cm × 4 cm) and were randomly allotted into four groups (n = 20) and subjected to 10 ml of experimental irrigating solutions for 5 min as follows, group 1: normal saline (Control), group 2: 5.
Comput Biol Med
September 2025
Mathematical Oncology Laboratory (MOLAB), Department of Mathematics, University of Castilla-La Mancha, Spain; Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Spain. Electronic address:
Recent biological research has highlighted the relevance of myeloid-cell populations in glioma growth, with a particular role played by tumor-associated macrophages (TAMs), which comprise resident microglia and monocyte-derived macrophages. Additionally, radiation therapy, the most common treatment for gliomas, significantly alters the tumor microenvironment, affecting TAMs and contributing to tumor recurrence. Promising preclinical studies have identified and developed drugs targeting TAMs.
View Article and Find Full Text PDFAging Clin Exp Res
August 2025
Department of Twin Research & Genetic Epidemiology, King's College London, 3rd Floor D Block South Wing, St Thomas' Campus, London, SE1 7EH, UK.
Background: The ageing population has led to more cancer cases among older adults, who face higher risks of treatment-related adverse events, functional decline, and unplanned healthcare use. Traditional assessments like Eastern Cooperative Oncology Group and Karnofsky Performance Status lack sensitivity for this group, highlighting the need for new methods to monitor symptoms and functional changes in cancer care. This review examines remote monitoring technologies for older adults with cancer, focusing on their potential and challenges.
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