Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Neurological disorders present a formidable challenge in healthcare, necessitating the continuous exploration of innovative therapeutic avenues. This review delves into the burgeoning field of natural diterpenoid derivatives and their promising role in addressing neurological disorders. Derived from natural sources, these compounds exhibit a diverse range of pharmacological properties, positioning them as potential agents for treating conditions such as Alzheimer's and Parkinson's disease. The review highlights recent advancements, shedding light on the multifaceted mechanisms through which diterpenoid derivatives exert their effects, from antiinflammatory to neuroprotective actions. As the scientific community navigates the translational journey from bench to bedside, integrating these natural compounds into neurotherapeutics emerges as a compelling prospect. This exploration of the therapeutic frontiers of natural diterpenoid derivatives signifies a significant step towards innovative and effective strategies in the management of neurological disorders. It highlights the potential of natural compounds to revolutionize neurotherapeutics.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/0113892010304266240507050825 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
sp. nov., a novel halotolerant, flexirubin-type pigment-producing bacterium of the family .
Int J Syst Evol Microbiol
September 2025
Second Institute of Oceanography, Key Laboratory of Marine Ecosystem Dynamics, Ministry of Natural Resources, Hangzhou 310018, PR China.
A Gram-staining-negative, non-motile, aerobic, rod-shaped bacterium, designated 14752, was isolated from a saline lake in Xinjiang Uygur Autonomous Region, China. The strain was subjected to a taxonomic study using a polyphasic approach. Strain 14752 was able to grow at 4-40 ℃ (optimum 28 ℃), pH 6.
View Article and Find Full Text PDFAsymmetric Mannich reaction enabled synthesis of alkaloids.
Mol Divers
September 2025
Department of Chemistry, College of Science, King Khalid University, P.O. Box 9004, 61413, Abha, Saudi Arabia.
The catalytic asymmetric Mannich reaction is a multicomponent reaction which affords β-amino carbonyl compounds by utilizing an aldehyde, a primary or secondary amine/ammonia, and a ketone. β-amino carbonyl scaffolds are crucial intermediates for the synthesis of naturally occurring bioactive compounds and their derivatives. The synthesized natural compounds exhibit a broad spectrum of biological activities including anti-fungal, anti-cancer, anti-bacterial, anti-HIV, anti-oxidant, and anti-inflammatory activities.
View Article and Find Full Text PDFCost-effectiveness of oil and milk fortification by scale for reducing Vitamin A and Vitamin D deficiency in India.
PLoS One
September 2025
Institute of Economic Growth, Delhi University Enclave (North Campus), Delhi, India.
Background: Although broad-scale data might suggest low prevalence, millions of children in India still suffer from Vitamin A and Vitamin D deficiencies despite India's existing guidelines for Vitamin A deficiency. To address the issue, the Government of India has recommended fortification of oil and milk to improve Vitamin A and Vitamin D consumption. However, there is limited information on the health benefits and cost-effectiveness of fortifying oil and milk at scale.
View Article and Find Full Text PDF3-O-acetylrubiarbonol B preferentially targets EGFR and MET over rubiarbonol B to inhibit NSCLC cell growth.
PLoS One
September 2025
Department of Biomedicine, Health and Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Muan, Republic of Korea.
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths, remaining a significant challenge in terms of early detection, effective treatment, and improving patient survival rates. In this study, we investigated the anticancer mechanism of rubiarbonol B (Ru-B) and its derivative 3-O-acetylrubiarbonol B (ARu-B), a pentacyclic terpenoid in gefitinib (GEF)-sensitive and -resistant NSCLC HCC827 cells. Concentration- and time-dependent cytotoxicity was observed for both Ru-B and ARu-B.
View Article and Find Full Text PDFSynthesis of 13C2-Retinyl Acetate and Dose Preparation for Retinol Isotope Dilution Tests.
J Vis Exp
August 2025
Department of Nutritional Sciences, University of Wisconsin-Madison;
The retinol isotope dilution (RID) test is the most sensitive method to assess vitamin A status by estimating total liver reserves, considered the reference standard. For gas chromatography-combustion-isotope ratio mass spectrometry detection, C is added to the retinol moiety. The synthetic procedure for C-retinyl acetate begins with the naturally occurring β-ionone.
View Article and Find Full Text PDF