Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Hydropower, although an attractive renewable energy source, can alter the flux of water, sediments, and biota, producing detrimental impacts in downstream regions. The Mekong River illustrates the impacts of large dams and the limitations of conventional dam regulating strategies. Even under the most optimistic sluicing scenario, sediment load at the Mekong Delta could only recover to 62.3 ± 8.2 million tonnes (1 million tonnes = 10 kilograms), short of the (100 to 160)-million tonne historical level. Furthermore, unless retrofit to reroute sediments, the dams are doomed to continue trapping sediment for at least 170 years and thus starve downstream reaches of sediment, contributing to the impending disappearance of the Mekong Delta. Therefore, we explicitly challenge the widespread use of large dead storages-the portion of the reservoirs that cannot be emptied-in dam designs. Smaller dead storages can ease sediment starvation in downstream regions, thereby buffering against sinking deltas or relative sea level rises.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11092995PMC
http://dx.doi.org/10.1126/sciadv.adn9731DOI Listing

Publication Analysis

Top Keywords

downstream regions
8
mekong delta
8
sediment
5
restoring water
4
water sediment
4
sediment fluxes
4
fluxes mega-dam
4
mega-dam cascade
4
cascade alleviate
4
alleviate sinking
4

Similar Publications

Background: Sodium homeostasis is crucial for physiological balance, yet the neurobiological mechanisms underlying sodium appetite remain incompletely understood. The nucleus tractus solitarii (NTS) integrates visceral signals to regulate feeding behaviors, including sodium intake. This study investigated the role of 11β-hydroxysteroid dehydrogenase type 2 (HSD2)-expressing neurons in the NTS in mediating sodium appetite under low-sodium diet (LSD) conditions and elucidated the molecular pathways involved, particularly the cyclic adenosine monophosphate (cAMP)/mitogen-activated protein kinase (MAPK) signaling cascade.

View Article and Find Full Text PDF

Recursive splice sites are rare motifs postulated to facilitate splicing across massive introns and shape isoform diversity, especially for long, brain-expressed genes. The necessity of this unique mechanism remains unsubstantiated, as does the role of recursive splicing (RS) in human disease. From analyses of rare copy number variants (CNVs) from almost one million individuals, we previously identified large, heterozygous deletions eliminating an RS site (RS1) in the first intron of that conferred substantial risk for attention deficit hyperactivity disorder (ADHD) and other neurobehavioral traits.

View Article and Find Full Text PDF

Snai2 is a transcription factor that inhibits the proliferation of cervical cancer cells and tumor growth. The expression of Snai2 inhibited the expression of β-catenin and impaired Wnt/β-catenin signaling pathway activity. The results of the RNA sequence in Snai2-overexpressing cervical cancer cells implied a strong correlation between Snai2 and TRIM31 with ubiquitin ligase activity.

View Article and Find Full Text PDF

Functional Validation of Noncoding Variants Associated With Nonsyndromic Orofacial Cleft.

Hum Mutat

September 2025

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Over the past decade, genome-wide association studies (GWASs) have found genetic variants associated with elevated risk for nonsyndromic orofacial cleft (NSOFC). In the post-GWAS era of NSOFC genetic research, an important aim is to identify the pathogenic variants that influence craniofacial development processes, towards understanding how they lead to disease manifestation. However, two major challenges hinder the translation of GWAS results into a mechanistic understanding.

View Article and Find Full Text PDF

: an R package to infer gene transcription rates with a novel least sum of squares method.

NAR Genom Bioinform

September 2025

Department of Internal Medicine, Nephrology Division, University of Michigan, Ann Arbor 48109 MI, United States.

The dynamics of transcriptional elongation influence many biological activities, such as RNA splicing, polyadenylation, and nuclear export. To quantify the elongation rate, a typical method is to treat cells with drugs that inhibit RNA polymerase II (Pol II) from entering the gene body and then track Pol II using Pro-seq or Gro-seq. However, the downstream data analysis is challenged by the problem of identifying the transition point between the gene regions inhibited by the drug and not, which is necessary to calculate the transcription rate.

View Article and Find Full Text PDF