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http://dx.doi.org/10.1007/s00210-024-03083-x | DOI Listing |
Front Mol Biosci
August 2025
Department of Biochemistry, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
[This corrects the article DOI: 10.3389/fmolb.2024.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Institute of Translational Pharmacology-National Research Council of Italy (IFT-CNR), 90146 Palermo, Italy.
The exposure to risk factors, such as cigarette smoke and air pollution (containing metabolic oxidants and toxic substances), leading to cellular and molecular alterations, promotes the development of lung cancer at multiple stages. The antioxidant defence system plays a critical role in counteracting the mechanisms of oxidative stress. In physiological conditions, the balance between pro-oxidant and antioxidant species is critically important for the correct performance of cellular functions.
View Article and Find Full Text PDFACS Appl Bio Mater
August 2025
Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu 600077, India.
The present study reports an eco-friendly route for the synthesis of chitosan-stabilized gold nanoparticles (Cs@AuNPs) using leaf extract and their dual anticancer and antimicrobial activities. The nanoparticles were comprehensively characterized by ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and ζ-potential analysis. Cs@AuNPs exhibited a strong surface plasmon resonance peak at 550 nm, face-centered cubic crystallinity with a predominant (111) plane, spherical morphology, particle size ranging from 5-30 nm, and a positive surface charge.
View Article and Find Full Text PDFInvest New Drugs
August 2025
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, 571448, B.G. Nagara, Karnataka, India.
The solute carrier (SLC) superfamily comprises a broad array of membrane-bound transport proteins that are integral to the intracellular uptake of various substrates, including nutrients, endogenous metabolites, and an expanding repertoire of anticancer drugs. Although they play a pivotal role in drug disposition and pharmacokinetics, SLC-mediated influx mechanisms have historically garnered less research attention compared to the extensively studied ATP-binding cassette (ABC) efflux transporters. Increasing evidence now indicates that the expression profiles, functional activity, and regulatory pathways of SLC transporters critically influence intracellular drug accumulation, therapeutic outcomes, and the emergence of resistance in cancer.
View Article and Find Full Text PDF